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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2006-11-28
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pubmed:abstractText |
Dominant epitope-specific CD8(+) T-lymphocyte responses play a central role in controlling viral spread. We explored the basis for the development of this focused immune response in simian immunodeficiency virus (SIV)- and simian-human immunodeficiency virus (SHIV)-infected rhesus monkeys through the use of two dominant (p11C and p199RY) and two subdominant (p68A and p56A) epitopes. Using real-time PCR to quantitate T-cell receptor (TCR) variable region beta (Vbeta) family usage, we show that CD8(+) T-lymphocyte populations specific for dominant epitopes are characterized by a diverse Vbeta repertoire, whereas those specific for subdominant epitopes employ a dramatically more focused Vbeta repertoire. We also demonstrate that dominant epitope-specific CD8(+) T lymphocytes employ TCRs with multiple CDR3 lengths, whereas subdominant epitope-specific cells employ TCRs with a more restricted CDR3 length. Thus, the relative dominance of an epitope-specific CD8(+) T-lymphocyte response reflects the clonal diversity of that response. These findings suggest that the limited clonal repertoire of subdominant epitope-specific CD8(+) T-lymphocyte populations may limit the ability of these epitope-specific T-lymphocyte populations to expand and therefore limit the ability of these cell populations to contribute to the control of viral replication.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-10227983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-10358753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-10364294,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-15258286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-1531206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-15555065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-15685174,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-2500349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-3029268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-7527444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-7535183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-7561698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-7585062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-7614990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-7682817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-7734044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-8207839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-8211163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-8393899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-8459219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-8477809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-8568249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-8810254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-9018241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-9100978,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-9345075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-9420212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-9458122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-9505090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-9565630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-9597133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-9637523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-9933172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035327-9973496
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
12032-40
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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