Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2006-11-28
pubmed:abstractText
The high prevalence of preexisting immunity to adenovirus serotype 5 (Ad5) in human populations has led to the development of recombinant adenovirus (rAd) vectors derived from rare Ad serotypes as vaccine candidates for human immunodeficiency virus type 1 and other pathogens. Vaccine vectors have been constructed from Ad subgroup B, including rAd11 and rAd35, as well as from Ad subgroup D, including rAd49. However, the optimal combination of vectors for heterologous rAd prime-boost vaccine regimens and the extent of cross-reactive vector-specific neutralizing antibodies (NAbs) remain poorly defined. We have shown previously that the closely related vectors rAd11 and rAd35 elicited low levels of cross-reactive NAbs. Here we show that these cross-reactive NAbs correlated with substantial sequence homology in the hexon hypervariable regions (HVRs) and suppressed the immunogenicity of heterologous rAd prime-boost regimens. In contrast, vectors with lower hexon HVR homology, such as rAd35 and rAd49, did not elicit detectable cross-reactive vector-specific NAbs. Consistent with these findings, rAd35-rAd49 vaccine regimens proved more immunogenic than both rAd35-rAd5 and rAd35-rAd11 regimens in mice with anti-Ad5 immunity. These data suggest that optimal heterologous rAd prime-boost regimens should include two vectors that are both rare in human populations to circumvent preexisting antivector immunity as well as sufficiently immunologically distinct to avoid cross-reactive antivector immunity.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-11117750, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-11238859, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-11689642, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-11797011, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-12477888, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-12538702, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-12743287, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-12857895, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-12885892, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-12904795, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-14605137, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-14746526, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-14990686, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-15128818, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-15166541, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-15220412, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-15520866, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-15542673, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-15905562, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-16014931, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-16254351, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-16625206, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-16963747, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-8627708, http://linkedlifedata.com/resource/pubmed/commentcorrection/17035318-8810254
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12009-16
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Immunogenicity of heterologous recombinant adenovirus prime-boost vaccine regimens is enhanced by circumventing vector cross-reactivity.
pubmed:affiliation
Research East Room 213, Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural