Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Pt 2
pubmed:dateCreated
1991-2-27
pubmed:abstractText
An account is given of the 6- to 12-month survival, and causes of failure in 110 consecutive patients who underwent primary liver transplantation under treatment from the outset with FK 506 and steroids. The patient survival is 92.7%, and the first graft survival is 87.3%. At a very high frequency, the patients achieved good graft function, and they had a relatively low morbidity that was partially ascribable to minimal use and early discontinuance (in 60% of cases) of steroids. Renal dysfunction and other adverse findings were largely confined to patients with poor initial graft function and consequent apparent alteration of the kinetics of FK 506 elimination, causing functional overdosage. Results compare very favorably with our past record using conventional immunosuppression, and support the belief that FK 506 is a superior immunosuppressive agent which is suitable for chronic administration.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Alanine Transaminase, http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents, http://linkedlifedata.com/resource/pubmed/chemical/Aspartate Aminotransferases, http://linkedlifedata.com/resource/pubmed/chemical/Bilirubin, http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, http://linkedlifedata.com/resource/pubmed/chemical/Creatine, http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporins, http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents, http://linkedlifedata.com/resource/pubmed/chemical/Prednisone, http://linkedlifedata.com/resource/pubmed/chemical/Tacrolimus, http://linkedlifedata.com/resource/pubmed/chemical/Uric Acid, http://linkedlifedata.com/resource/pubmed/chemical/gamma-Glutamyltransferase
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0041-1345
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1397-402
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:1703340-Adult, pubmed-meshheading:1703340-Alanine Transaminase, pubmed-meshheading:1703340-Anti-Bacterial Agents, pubmed-meshheading:1703340-Aspartate Aminotransferases, pubmed-meshheading:1703340-Bilirubin, pubmed-meshheading:1703340-Blood Urea Nitrogen, pubmed-meshheading:1703340-Cause of Death, pubmed-meshheading:1703340-Cholesterol, pubmed-meshheading:1703340-Creatine, pubmed-meshheading:1703340-Cyclosporins, pubmed-meshheading:1703340-Graft Survival, pubmed-meshheading:1703340-Humans, pubmed-meshheading:1703340-Hypertension, pubmed-meshheading:1703340-Immunosuppression, pubmed-meshheading:1703340-Immunosuppressive Agents, pubmed-meshheading:1703340-Jaundice, pubmed-meshheading:1703340-Kidney, pubmed-meshheading:1703340-Liver Transplantation, pubmed-meshheading:1703340-Prednisone, pubmed-meshheading:1703340-Survival Analysis, pubmed-meshheading:1703340-Tacrolimus, pubmed-meshheading:1703340-Uric Acid, pubmed-meshheading:1703340-gamma-Glutamyltransferase
pubmed:year
1991
pubmed:articleTitle
One hundred ten consecutive primary orthotopic liver transplants under FK 506 in adults.
pubmed:affiliation
Department of Surgery, University of Pittsburgh, PA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.