Linked Life Data

17033202

Source:http://linkedlifedata.com/resource/pubmed/id/17033202

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-10-26
pubmed:abstractText
Recent molecular epidemiological studies have revealed a possible association of the acetaldehyde dehydrogenase-2 (ALDH2) 1510 G/A (Glu487Lys) polymorphism with various cancers including head and neck squamous cell carcinoma (HNSCC). To further elucidate the significance of this polymorphism in HNSCC development, the relationship between ALDH2 1510 G/A and clinicopathological parameters, cigarette smoking or alcohol intake was evaluated in patients with HNSCC. DNA samples from 192 patients with primary HNSCC and 192 age- and gender-matched healthy controls were genotyped and statistically evaluated. Although there was no significant difference in the genotype distribution of ALDH2 1510 G/A between cases and controls, we found that the frequency of the ALDH2 genotypes with the mutated A (Lys) allele was greater in patients aged <66 years than in those aged > or = 66 years (p = 0.034). This tendency became more evident in patients with the habit of drinking (n = 143; p = 0.009). The association of ALDH2 1510 G/A with age remained significant after multivariate logistic regression analysis was performed for the patients (odds ratio for an age interval for 1 year, 0.970; 95% confidence interval, 0.943-0.998). The present data suggest a possible interaction between the ALDH2 1510 G/A polymorphism and age in HNSCC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1010-4283
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2006 S. Karger AG, Basel.
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
334-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
ALDH2 1510 G/A (Glu487Lys) polymorphism interaction with age in head and neck squamous cell carcinoma.
pubmed:affiliation
Department of Otolaryngology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
pubmed:publicationType
Journal Article, Comparative Study