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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-12-14
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pubmed:abstractText |
Sclerostin is an osteocyte-derived negative regulator of bone formation. It inhibits BMP-stimulated bone formation both in vitro and in vivo but has no direct effect on BMP signaling. Instead, sclerostin inhibits Wnt signaling that is required for BMP-stimulated osteoblastic differentiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BMP4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bmp4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 4,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Genetic Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sost protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0884-0431
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pubmed:author |
pubmed-author:EeftingDaniëlD,
pubmed-author:KarperienMarcelM,
pubmed-author:LöwikClemens W G MCW,
pubmed-author:PapapoulosSocrates ESE,
pubmed-author:QuaxPaul H APH,
pubmed-author:SvenssonJ PeterJP,
pubmed-author:VisserAnnemiekeA,
pubmed-author:VrielingHarryH,
pubmed-author:ten DijkePeterP,
pubmed-author:van BezooijenRutger LRL,
pubmed-author:van der HorstGeertjeG
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
19-28
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17032150-Animals,
pubmed-meshheading:17032150-Bone Development,
pubmed-meshheading:17032150-Bone Morphogenetic Protein 4,
pubmed-meshheading:17032150-Bone Morphogenetic Proteins,
pubmed-meshheading:17032150-Cells, Cultured,
pubmed-meshheading:17032150-Electroporation,
pubmed-meshheading:17032150-Gene Expression Regulation,
pubmed-meshheading:17032150-Genes, Reporter,
pubmed-meshheading:17032150-Genetic Markers,
pubmed-meshheading:17032150-Glycoproteins,
pubmed-meshheading:17032150-Humans,
pubmed-meshheading:17032150-Mesoderm,
pubmed-meshheading:17032150-Mice,
pubmed-meshheading:17032150-Muscle, Skeletal,
pubmed-meshheading:17032150-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:17032150-Recombinant Proteins,
pubmed-meshheading:17032150-Signal Transduction,
pubmed-meshheading:17032150-Transfection,
pubmed-meshheading:17032150-Wnt Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation.
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pubmed:affiliation |
Department of Endocrinology and Metabolic Diseases, Leiden Univerity Medical Center, Ther Netherlands. R.L.van_Bezooyen@lumc.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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