| pubmed-article:1703180 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1703180 | lifeskim:mentions | umls-concept:C0014520 | lld:lifeskim |
| pubmed-article:1703180 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:1703180 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:1703180 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:1703180 | lifeskim:mentions | umls-concept:C1622501 | lld:lifeskim |
| pubmed-article:1703180 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:1703180 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:1703180 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1703180 | pubmed:dateCreated | 1991-2-25 | lld:pubmed |
| pubmed-article:1703180 | pubmed:abstractText | Although it is well known that in various T cell-mediated skin diseases T cells migrate preferentially to epidermis, no direct evidence has been presented in which molecules on T cells are important in directing T cell traffic to epidermis. We have previously established CD4+ autoreactive cloned T cells with a special tropism for epidermis in vitro as well as in vivo. Antibody inhibition studies demonstrated that only anti-lymphocyte function associated Ag 1 (anti-LFA-1) mAb completely inhibited the in vitro migration of the T cells toward the epidermis, whereas mAb against other T cell surface molecules had little or no effect. Monovalent F(ab) fragment of the anti-LFA-1 mAb, although less efficient, also inhibited the T cell migration. The apparent dependency of the inhibition on the anti-alpha-chain mAb suggested a major role for the alpha-chain of LFA-1 in T cell migration to epidermis. The relevance of an LFA-1-dependent mechanism to the epidermotropic migration of T cells was further strengthened by the findings that the T cell migration to epidermis was inhibited by divalent cation depletion, cytochalasin B, and low temperature. These findings indicate that the LFA-1 molecule, which is thought to be primarily involved in cell-to-cell adhesions, also plays an important role in directing T cell migration to epidermis. | lld:pubmed |
| pubmed-article:1703180 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1703180 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1703180 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:1703180 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1703180 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1703180 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1703180 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1703180 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1703180 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1703180 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1703180 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1703180 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1703180 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:1703180 | pubmed:author | pubmed-author:MoriyaNN | lld:pubmed |
| pubmed-article:1703180 | pubmed:author | pubmed-author:NagashimaMM | lld:pubmed |
| pubmed-article:1703180 | pubmed:author | pubmed-author:GotohCC | lld:pubmed |
| pubmed-article:1703180 | pubmed:author | pubmed-author:ShioharaTT | lld:pubmed |
| pubmed-article:1703180 | pubmed:author | pubmed-author:YagitaHH | lld:pubmed |
| pubmed-article:1703180 | pubmed:author | pubmed-author:SaizawaKK | lld:pubmed |
| pubmed-article:1703180 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1703180 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:1703180 | pubmed:volume | 146 | lld:pubmed |
| pubmed-article:1703180 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1703180 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1703180 | pubmed:pagination | 840-5 | lld:pubmed |
| pubmed-article:1703180 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1703180 | pubmed:meshHeading | pubmed-meshheading:1703180-... | lld:pubmed |
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| pubmed-article:1703180 | pubmed:meshHeading | pubmed-meshheading:1703180-... | lld:pubmed |
| pubmed-article:1703180 | pubmed:meshHeading | pubmed-meshheading:1703180-... | lld:pubmed |
| pubmed-article:1703180 | pubmed:meshHeading | pubmed-meshheading:1703180-... | lld:pubmed |
| pubmed-article:1703180 | pubmed:meshHeading | pubmed-meshheading:1703180-... | lld:pubmed |
| pubmed-article:1703180 | pubmed:meshHeading | pubmed-meshheading:1703180-... | lld:pubmed |
| pubmed-article:1703180 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1703180 | pubmed:articleTitle | Evidence for involvement of lymphocyte function-associated antigen 1 in T cell migration to epidermis. | lld:pubmed |
| pubmed-article:1703180 | pubmed:affiliation | Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan. | lld:pubmed |
| pubmed-article:1703180 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1703180 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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