| pubmed-article:17030569 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17030569 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:17030569 | lifeskim:mentions | umls-concept:C0005715 | lld:lifeskim |
| pubmed-article:17030569 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:17030569 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:17030569 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:17030569 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:17030569 | lifeskim:mentions | umls-concept:C1879648 | lld:lifeskim |
| pubmed-article:17030569 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17030569 | pubmed:dateCreated | 2006-12-21 | lld:pubmed |
| pubmed-article:17030569 | pubmed:abstractText | Immunization with a cell wall/membrane (CW/M) and yeast cytosol extract (YCE) crude antigen from Blastomyces dermatitidis confers T-cell-mediated resistance against lethal experimental infection in mice. We isolated and characterized T cells that recognize components of these protective antigens and mediate protection. CD4+ T-cell clones elicited with CW/M antigen adoptively transferred protective immunity when they expressed a V alpha2+ J alpha49+/V beta1+ J beta1.1+ heterodimeric T-cell receptor (TCR) and produced high levels of gamma interferon (IFN-gamma). In contrast, V beta8.1/8.2+ CD4+ T-cell clones that were reactive against CW/M and YCE antigens and produced little or no IFN-gamma either failed to mediate protection or exacerbated the infection depending on the level of interleukin-5 expression. Thus, the outgrowth of protective T-cell clones against immunodominant antigens of B. dermatitidis is biased by a combination of the TCR repertoire and Th1 cytokine production. | lld:pubmed |
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| pubmed-article:17030569 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17030569 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17030569 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17030569 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17030569 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17030569 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:17030569 | pubmed:author | pubmed-author:KleinBruce... | lld:pubmed |
| pubmed-article:17030569 | pubmed:author | pubmed-author:WüthrichMarce... | lld:pubmed |
| pubmed-article:17030569 | pubmed:author | pubmed-author:AllenHolly... | lld:pubmed |
| pubmed-article:17030569 | pubmed:author | pubmed-author:FilutowiczHan... | lld:pubmed |
| pubmed-article:17030569 | pubmed:author | pubmed-author:DeepeGeorge... | lld:pubmed |
| pubmed-article:17030569 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17030569 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:17030569 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17030569 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17030569 | pubmed:pagination | 193-200 | lld:pubmed |
| pubmed-article:17030569 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:17030569 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17030569 | pubmed:articleTitle | V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis. | lld:pubmed |
| pubmed-article:17030569 | pubmed:affiliation | Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospitals and Clinics, Madison, WI 53792, USA. mwuethri@wisc.edu | lld:pubmed |
| pubmed-article:17030569 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17030569 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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