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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-12-21
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pubmed:abstractText |
Immunization with a cell wall/membrane (CW/M) and yeast cytosol extract (YCE) crude antigen from Blastomyces dermatitidis confers T-cell-mediated resistance against lethal experimental infection in mice. We isolated and characterized T cells that recognize components of these protective antigens and mediate protection. CD4+ T-cell clones elicited with CW/M antigen adoptively transferred protective immunity when they expressed a V alpha2+ J alpha49+/V beta1+ J beta1.1+ heterodimeric T-cell receptor (TCR) and produced high levels of gamma interferon (IFN-gamma). In contrast, V beta8.1/8.2+ CD4+ T-cell clones that were reactive against CW/M and YCE antigens and produced little or no IFN-gamma either failed to mediate protection or exacerbated the infection depending on the level of interleukin-5 expression. Thus, the outgrowth of protective T-cell clones against immunodominant antigens of B. dermatitidis is biased by a combination of the TCR repertoire and Th1 cytokine production.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-10209038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-11104791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-11160354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-116580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-12198616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-12421963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-12471131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-12697305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-12782709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-14661066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-16210634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-16622023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-1836010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-1948049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-1987047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-646221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-8412644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-8451641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17030569-9727067
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
193-200
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17030569-Adoptive Transfer,
pubmed-meshheading:17030569-Animals,
pubmed-meshheading:17030569-Antigens, Fungal,
pubmed-meshheading:17030569-Blastomyces,
pubmed-meshheading:17030569-Blastomycosis,
pubmed-meshheading:17030569-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17030569-Cell Line,
pubmed-meshheading:17030569-Cell Membrane,
pubmed-meshheading:17030569-Cell Wall,
pubmed-meshheading:17030569-Clone Cells,
pubmed-meshheading:17030569-Flow Cytometry,
pubmed-meshheading:17030569-Immune Tolerance,
pubmed-meshheading:17030569-Interferon-gamma,
pubmed-meshheading:17030569-Male,
pubmed-meshheading:17030569-Mice,
pubmed-meshheading:17030569-Mice, Inbred BALB C,
pubmed-meshheading:17030569-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:17030569-Yeasts
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pubmed:year |
2007
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pubmed:articleTitle |
V beta1+ J beta1.1+/V alpha2+ J alpha49+ CD4+ T cells mediate resistance against infection with Blastomyces dermatitidis.
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pubmed:affiliation |
Department of Pediatrics, University of Wisconsin Medical School, University of Wisconsin Hospitals and Clinics, Madison, WI 53792, USA. mwuethri@wisc.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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