Linked Life Data

17030430

Source:http://linkedlifedata.com/resource/pubmed/id/17030430

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2006-10-27
pubmed:abstractText
The laboratory mouse has emerged as a primary model organism for studying axon regeneration after experimental spinal cord injury, owing to its genetic amenability. Mutant mouse models are contributing significantly to our understanding of the molecular mechanisms of axon regeneration failure in the adult mammalian central nervous system (CNS), in particular regarding the role of axon-growth inhibitors. Here, we discuss recent advances in understanding axon regeneration failure that have been made using genetically modified mice, focusing on the inhibitory influences in the CNS, and we illustrate the advantages of using the mouse as a surrogate organism to study axon regeneration and spinal cord repair.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0166-2236
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
640-6
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Genetic mouse models for studying inhibitors of spinal axon regeneration.
pubmed:affiliation
Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0691, USA. binhai@ucsd.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't