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rdf:type |
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lifeskim:mentions |
umls-concept:C0012472,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0037083,
umls-concept:C0038351,
umls-concept:C0521115,
umls-concept:C0596263,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1710082,
umls-concept:C1879547
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pubmed:issue |
4
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pubmed:dateCreated |
2006-10-10
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pubmed:abstractText |
Accumulating evidence indicates that prostaglandin E(2) (PGE(2)), a downstream product of cyclooxygenase 2 (COX-2), plays a key role in gastric tumorigenesis. The Wnt pathway is also suggested to play a causal role in gastric carcinogenesis. However, the molecular mechanism remains poorly understood of how the Wnt and PGE(2) pathways contribute to gastric tumorigenesis. To investigate the role of Wnt and PGE(2) in gastric cancer, we have generated transgenic mice that activate both pathways and examined their phenotypes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1086-95
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pubmed:meshHeading |
pubmed-meshheading:17030179-Animals,
pubmed-meshheading:17030179-Cell Differentiation,
pubmed-meshheading:17030179-Cell Division,
pubmed-meshheading:17030179-Cyclooxygenase 2,
pubmed-meshheading:17030179-Dinoprostone,
pubmed-meshheading:17030179-Epithelial Cells,
pubmed-meshheading:17030179-Gastric Mucosa,
pubmed-meshheading:17030179-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17030179-Intramolecular Oxidoreductases,
pubmed-meshheading:17030179-Keratin-19,
pubmed-meshheading:17030179-Macrophages, Peritoneal,
pubmed-meshheading:17030179-Metaplasia,
pubmed-meshheading:17030179-Mice,
pubmed-meshheading:17030179-Mice, Inbred C57BL,
pubmed-meshheading:17030179-Mice, Transgenic,
pubmed-meshheading:17030179-Precancerous Conditions,
pubmed-meshheading:17030179-Signal Transduction,
pubmed-meshheading:17030179-Stem Cells,
pubmed-meshheading:17030179-Stomach Neoplasms,
pubmed-meshheading:17030179-Wnt1 Protein
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pubmed:year |
2006
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pubmed:articleTitle |
Carcinogenesis in mouse stomach by simultaneous activation of the Wnt signaling and prostaglandin E2 pathway.
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pubmed:affiliation |
Division of Genetics, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan. oshimam@kenroku.kanazawa-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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