Linked Life Data

17029912

Source:http://linkedlifedata.com/resource/pubmed/id/17029912

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-3-2
pubmed:abstractText
It has been proposed that some neuroadaptations that underlie behavioral sensitization may play a role in the development and persistence of addiction. However, whether or not sensitization facilitates the development of symptoms specific to addiction, such as the escalation of drug intake, is not known. We examined, therefore, the effect of pretreatment with a sensitizing regimen of amphetamine on the escalation of subsequent drug intake in rats given the opportunity to self-administer cocaine. Amphetamine pretreatment produced psychomotor sensitization and also accelerated the subsequent escalation of cocaine intake. This suggests that the neural circuits that are altered as a consequence of repeated amphetamine treatment, and the induction of sensitization, may overlap with those responsible for the development of some addiction-like behaviors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0924-977X
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
352-7
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Amphetamine pretreatment accelerates the subsequent escalation of cocaine self-administration behavior.
pubmed:affiliation
Department of Psychology (Biopsychology), The University of Michigan, 530 Church Street, Ann Arbor, MI 48109-1304, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural