Linked Life Data

17029799

Source:http://linkedlifedata.com/resource/pubmed/id/17029799

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-11-7
pubmed:abstractText
Occipital artery (OA) injections of 5-HT elicit pronounced reductions in heart rate and mean arterial blood pressure (MAP) in urethane-anesthetized rats by activation of vagal afferent cell bodies in the ipsilateral nodose ganglion. In contrast, internal carotid artery (ICA) and i.v. injections elicit similar cardiovascular responses by activation of peripheral vagal afferent terminals. The aim of this study was to examine the roles of 5-HT3 and 5-HT2 receptors in the 5-HT-induced activation of vagal afferent cell bodies and peripheral afferent terminals in urethane-anesthetized rats. OA, ICA and i.v. injections of 5-HT elicited dose-dependent reductions in heart rate and MAP that were virtually abolished after i.v. administration of the 5-HT3 receptor antagonists, MDL 7222 or ICS 205-930. The responses elicited by the OA injections of 5-HT were markedly diminished after i.v. injection of the 5-HT2 receptor antagonists, xylamidine or ketanserin, whereas the responses elicited by i.v. or ICA injections of 5-HT were not affected. The present findings suggest that (1) 5-HT3 and 5-HT2 receptor antagonists gain ready access to nodose ganglion cells upon i.v. administration, and (2) functional 5-HT3 and 5-HT2 receptors exist on the cell bodies of vagal afferent neurons mediating the cardiovascular responses elicited by OA injections of 5-HT. These findings also support a wealth of evidence that 5-HT3 receptors exist on the peripheral terminals of vagal afferents, and although they do not discount the possibility that 5-HT2 receptors exist on peripheral vagal afferent terminals, it appears that activation of these receptors does not have pronounced effects on 5-HT3 receptor activity on terminals that mediate the hemodynamic responses to 5-HT.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
143
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-87
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:17029799-Analysis of Variance, pubmed-meshheading:17029799-Animals, pubmed-meshheading:17029799-Atropine, pubmed-meshheading:17029799-Blood Pressure, pubmed-meshheading:17029799-Dose-Response Relationship, Drug, pubmed-meshheading:17029799-Drug Administration Routes, pubmed-meshheading:17029799-Drug Interactions, pubmed-meshheading:17029799-Heart Rate, pubmed-meshheading:17029799-Male, pubmed-meshheading:17029799-Muscarinic Antagonists, pubmed-meshheading:17029799-Neurons, Afferent, pubmed-meshheading:17029799-Rats, pubmed-meshheading:17029799-Rats, Sprague-Dawley, pubmed-meshheading:17029799-Receptors, Serotonin, 5-HT2, pubmed-meshheading:17029799-Receptors, Serotonin, 5-HT3, pubmed-meshheading:17029799-Serotonin, pubmed-meshheading:17029799-Serotonin Antagonists, pubmed-meshheading:17029799-Serotonin Receptor Agonists, pubmed-meshheading:17029799-Vagus Nerve
pubmed:year
2006
pubmed:articleTitle
5-HT activates vagal afferent cell bodies in vivo: role of 5-HT2 and 5-HT3 receptors.
pubmed:affiliation
Department of Pharmacology, University of Iowa, Iowa City, IA 55242, USA. Patrick.Lacolley@nancy.inserm.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't