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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-12-25
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pubmed:abstractText |
High-throughput screening of the UCB sample collection identified the piperidinyl-sulfonyl benzoic ester 1 as a novel agonist for CB(1) receptor with nanomolar affinity. We report here the pharmacological profile of compound 1 as well as preliminary biological activities in pain model. Diverse close analogs of 1 were purchased and the structure-affinity relationships among this novel class are discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
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|
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
272-7
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pubmed:meshHeading |
pubmed-meshheading:17027269-Analgesics,
pubmed-meshheading:17027269-Animals,
pubmed-meshheading:17027269-Benzoates,
pubmed-meshheading:17027269-Humans,
pubmed-meshheading:17027269-Ligands,
pubmed-meshheading:17027269-Male,
pubmed-meshheading:17027269-Mice,
pubmed-meshheading:17027269-Mice, Inbred Strains,
pubmed-meshheading:17027269-Receptor, Cannabinoid, CB1,
pubmed-meshheading:17027269-Structure-Activity Relationship,
pubmed-meshheading:17027269-Sulfonamides
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
Arylsulfonamides as a new class of cannabinoid CB1 receptor ligands: identification of a lead and initial SAR studies.
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|
pubmed:affiliation |
CNS Molecular and Cellular Biology, Centre for CNS Innovation, UCB S.A., Chemin du Foriest, B-1420 Braine L'Alleud, Belgium.
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pubmed:publicationType |
Journal Article
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