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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1991-2-20
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pubmed:abstractText |
CD27 is present on the surface of a major subset of peripheral blood T lymphocytes. In this report we show that CD27 is also expressed on a subpopulation of the normal human B cell lineage which is absent from cord blood but present in tonsils and in the peripheral blood of adult individuals. CD27+ B lymphocytes are characterized by the following criteria: (a) in terms of physical properties, the CD27+ B cells form a population with an increased cell size combined with a decreased cell density; (b) the CD27 expression of tonsillar B lymphocytes is postively correlated with mIgA but negatively correlated with membrane IgM/membrane IgD positivity; (c) CD27 on B cells can be induced selectively by the combination of Staphylococcus aureus plus interleukin 2, but not by either treatment alone, and (d) CD27+ B lymphocytes express high levels of the adhesion structures LFA-1 (CD11a), ICAM-1 (CD54), LFA-3 (CD58) and of the lymphocyte homing receptor CD44. These latter findings suggest that CD27+ B cells are predispose to form cell-cell interactions. Accordingly, within 3 h of cell culture CD27+, but not CD27-, B lymphocytes were found to form LFA-1-mediated homotypic B cell clusters.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD27,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD5,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin D,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2679-84
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1702722-Antibodies, Monoclonal,
pubmed-meshheading:1702722-Antigens, CD,
pubmed-meshheading:1702722-Antigens, CD27,
pubmed-meshheading:1702722-Antigens, CD5,
pubmed-meshheading:1702722-Antigens, Differentiation,
pubmed-meshheading:1702722-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:1702722-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:1702722-B-Lymphocyte Subsets,
pubmed-meshheading:1702722-Cell Adhesion Molecules,
pubmed-meshheading:1702722-Cell Aggregation,
pubmed-meshheading:1702722-Cell Differentiation,
pubmed-meshheading:1702722-Cells, Cultured,
pubmed-meshheading:1702722-Flow Cytometry,
pubmed-meshheading:1702722-Humans,
pubmed-meshheading:1702722-Immunoglobulin D,
pubmed-meshheading:1702722-Lymphocyte Activation,
pubmed-meshheading:1702722-Palatine Tonsil,
pubmed-meshheading:1702722-Receptors, Antigen, B-Cell
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pubmed:year |
1990
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pubmed:articleTitle |
CD27 expression by a distinct subpopulation of human B lymphocytes.
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pubmed:affiliation |
Institute of Immunology, Vienna International Research Cooperation Center, Austria.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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