Linked Life Data

17026454

Source:http://linkedlifedata.com/resource/pubmed/id/17026454

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-10-9
pubmed:abstractText
Metastasis, or tumor growth in an ectopic site, may occur several years after apparently successful treatment of the primary malignancy. Clinical dormancy is seen in a large number of cancer patients, but once growth in an ectopic site initiates, current adjuvant therapies are inadequate and the majority of patients with metastatic disease will die. Many genes may regulate ectopic growth in a secondary site, including a small subset, termed the metastasis suppressor genes. Investigation into this class of genes holds promise in terms of gaining a greater understanding of tumor dormancy and how the process of metastasis may be naturally inhibited. This review will focus on the role of metastasis suppressor genes in tumor dormancy. Insights into the metastatic process from studies of metastasis suppressor genes may lead to novel targets for antimetastatic therapy through drug-induced reactivation of one or more of these genes and/or their respective signaling pathways.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1479-6694
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
627-41
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Tumor dormancy and the role of metastasis suppressor genes in regulating ectopic growth.
pubmed:affiliation
University of Western Ontario, Schulich School of Medicine & Dentistry, London Regional Cancer Program, Department of Oncology, London, Ontario, Canada. ben.hedley@lhsc.on.ca
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't