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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-10-31
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pubmed:abstractText |
Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and of cardiovascular and cerebrovascular complications. Transforming growth factor-beta1 (TGF-beta1) is a pleiotropic cytokine with a central role in inflammation. Little is known of the relation of variations within the gene and risk of cardiovascular and cerebrovascular disease. We therefore investigated 5 polymorphisms in the TGF-beta1 gene (-800 G/A, -509 C/T, codon 10 Leu/Pro, codon 25 Arg/Pro, and codon 263 Thr/Ile) in relation to the risk of myocardial infarction and stroke in a population-based study.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1524-4628
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2667-71
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17023672-Aged,
pubmed-meshheading:17023672-Aged, 80 and over,
pubmed-meshheading:17023672-Alleles,
pubmed-meshheading:17023672-Cohort Studies,
pubmed-meshheading:17023672-Female,
pubmed-meshheading:17023672-Follow-Up Studies,
pubmed-meshheading:17023672-Genetic Predisposition to Disease,
pubmed-meshheading:17023672-Humans,
pubmed-meshheading:17023672-Male,
pubmed-meshheading:17023672-Middle Aged,
pubmed-meshheading:17023672-Myocardial Infarction,
pubmed-meshheading:17023672-Netherlands,
pubmed-meshheading:17023672-Polymorphism, Genetic,
pubmed-meshheading:17023672-Prospective Studies,
pubmed-meshheading:17023672-Risk Factors,
pubmed-meshheading:17023672-Stroke,
pubmed-meshheading:17023672-Transforming Growth Factor beta,
pubmed-meshheading:17023672-Transforming Growth Factor beta1
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pubmed:year |
2006
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pubmed:articleTitle |
TGF-beta 1 polymorphisms and risk of myocardial infarction and stroke: the Rotterdam Study.
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pubmed:affiliation |
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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