Source:http://linkedlifedata.com/resource/pubmed/id/17023095
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
13
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pubmed:dateCreated |
2007-3-12
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pubmed:abstractText |
The long-term immunogenicity and vaccine efficacy (VE) of a 9-valent conjugate pneumococcal vaccine was studied in HIV infected and HIV non-infected children. VE against vaccine-serotype invasive pneumococcal disease following 6.16 years of follow-up persisted in HIV non-infected children (77.8%; 95% CI 34.4-92.5 compared to 83% after 2.3 years of follow-up), and declined from 65% to 38.8% (95% CI -7.8 to 65.2) in HIV infected children. HIV non-infected vaccinees had equal (serotypes 4, 6B, 14, 19F) or greater (serotypes 9V, 18C, 23F) proportions of serotype-specific antibody concentrations of > or =0.2microg/ml to vaccine-serotypes analyzed compared to HIV infected vaccinees at 5.3 years of age.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0264-410X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2451-7
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17023095-Antibody Formation,
pubmed-meshheading:17023095-Child,
pubmed-meshheading:17023095-Child, Preschool,
pubmed-meshheading:17023095-Double-Blind Method,
pubmed-meshheading:17023095-Female,
pubmed-meshheading:17023095-HIV,
pubmed-meshheading:17023095-HIV Infections,
pubmed-meshheading:17023095-Humans,
pubmed-meshheading:17023095-Immunization, Secondary,
pubmed-meshheading:17023095-Infant,
pubmed-meshheading:17023095-Male,
pubmed-meshheading:17023095-Pneumococcal Infections,
pubmed-meshheading:17023095-Pneumococcal Vaccines,
pubmed-meshheading:17023095-Streptococcus pneumoniae,
pubmed-meshheading:17023095-Treatment Outcome,
pubmed-meshheading:17023095-Vaccines, Conjugate
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pubmed:year |
2007
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pubmed:articleTitle |
Long-term immunogenicity and efficacy of a 9-valent conjugate pneumococcal vaccine in human immunodeficient virus infected and non-infected children in the absence of a booster dose of vaccine.
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pubmed:affiliation |
University of the Witwatersrand/Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, South Africa. madhis@hivas.com
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase III,
Research Support, N.I.H., Extramural
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