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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-4-23
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pubmed:abstractText |
The most prevalent LQT1 form of inherited long QT syndrome is caused by mutations of the KCNQ1 gene resulting repolarizing I(Ks) potassium current to decrease and the QT interval to prolong. As abrupt sympathetic activation triggers ventricular arrhythmias that may cause syncopal attacks and sudden death in LQT1 patients, we investigated whether two known beta1-adrenergic receptor polymorphisms were associated with the duration of QT interval or history of symptoms in LQT1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1874-1754
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
31
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
197-202
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pubmed:meshHeading |
pubmed-meshheading:17023080-Adolescent,
pubmed-meshheading:17023080-Adult,
pubmed-meshheading:17023080-Aged,
pubmed-meshheading:17023080-Aged, 80 and over,
pubmed-meshheading:17023080-Electrocardiography,
pubmed-meshheading:17023080-Exercise Test,
pubmed-meshheading:17023080-Female,
pubmed-meshheading:17023080-Finland,
pubmed-meshheading:17023080-Genotype,
pubmed-meshheading:17023080-Humans,
pubmed-meshheading:17023080-KCNQ1 Potassium Channel,
pubmed-meshheading:17023080-Long QT Syndrome,
pubmed-meshheading:17023080-Male,
pubmed-meshheading:17023080-Middle Aged,
pubmed-meshheading:17023080-Mutation,
pubmed-meshheading:17023080-Odds Ratio,
pubmed-meshheading:17023080-Polymorphism, Genetic,
pubmed-meshheading:17023080-Receptors, Adrenergic, beta-1,
pubmed-meshheading:17023080-Reference Values,
pubmed-meshheading:17023080-Regression Analysis
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pubmed:year |
2007
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pubmed:articleTitle |
Beta1-adrenergic receptor polymorphisms, QTc interval and occurrence of symptoms in type 1 of long QT syndrome.
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pubmed:affiliation |
Department of Medicine, University of Helsinki, 00290 Helsinki, Finland. kristian.paavonen@hus.fi
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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