Source:http://linkedlifedata.com/resource/pubmed/id/17022955
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2006-11-6
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| pubmed:abstractText |
Schizophrenia may result from altered gene expression leading to abnormal neurodevelopment. In a search for genes with altered expression in schizophrenia, our previous work on human frontal cerebral cortex found the mRNA of Nogo, a myelin-associated protein which inhibits the outgrowth of neurites and nerve terminals, to be overexpressed in schizophrenia. Because those earlier results did not examine tissues for the separate Nogo A, B and C isoforms from age- and sex-matched individuals, we repeated the study for all three isoforms, using a new set of tissues from matched individuals, and using the more accurate method of quantitative real-time PCR (polymerase chain reaction). We found Nogo C to be overexpressed by 26% in the schizophrenia tissues, which is in accordance with our earlier results. The expression of Nogo B was statistically significantly reduced by 17% in the frontal cortices from individuals who had been diagnosed as having had severe depression. Furthermore, we show that there is a direct correlation between the expression of Nogo A and C and the presence of alleles with a CAA insert, irrespective of disease status. While upregulation of Nogo C expression may play a role in schizophrenia, altered Nogo B may contribute to the clinical condition of depression. Nogo A showed a statistically non-significant increase in expression in schizophrenia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3' Untranslated Regions,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nogo protein,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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| pubmed:status |
MEDLINE
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| pubmed:month |
Nov
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| pubmed:issn |
0006-8993
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
20
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| pubmed:volume |
1120
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
161-71
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| pubmed:meshHeading |
pubmed-meshheading:17022955-3' Untranslated Regions,
pubmed-meshheading:17022955-Adult,
pubmed-meshheading:17022955-Bipolar Disorder,
pubmed-meshheading:17022955-DNA, Complementary,
pubmed-meshheading:17022955-Depression,
pubmed-meshheading:17022955-Female,
pubmed-meshheading:17022955-Frontal Lobe,
pubmed-meshheading:17022955-Gene Expression,
pubmed-meshheading:17022955-Gene Frequency,
pubmed-meshheading:17022955-Genetic Predisposition to Disease,
pubmed-meshheading:17022955-Humans,
pubmed-meshheading:17022955-Male,
pubmed-meshheading:17022955-Middle Aged,
pubmed-meshheading:17022955-Myelin Proteins,
pubmed-meshheading:17022955-Polymorphism, Genetic,
pubmed-meshheading:17022955-Postmortem Changes,
pubmed-meshheading:17022955-Protein Isoforms,
pubmed-meshheading:17022955-RNA, Messenger,
pubmed-meshheading:17022955-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17022955-Schizophrenia
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| pubmed:year |
2006
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| pubmed:articleTitle |
Nogo A, B and C expression in schizophrenia, depression and bipolar frontal cortex, and correlation of Nogo expression with CAA/TATC polymorphism in 3'-UTR.
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| pubmed:affiliation |
Department of Pharmacology, Medical Sciences Building 4344, University of Toronto, 1 King's College Circle, Toronto, Canada M5S 1A8.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|