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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
4
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pubmed:dateCreated |
1976-1-2
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pubmed:abstractText |
A transformed mouse cell line (H238) was obtained following the infection of 238 mouse cells with ultraviolet (UV) irradiation-inactivated herpes simplex virus type 2 (HSV-2). The transformed cells produced tumors with a 100% incidence within 8 weeks in 6-week-old syngeneic BALB/c mice at an inoculum of 1 times 10(6). Indirect immunofluorescence (IF) tests revealed the presence of HSV antigens in the transformed cells. Antibodies to HSV-2 were found in the sera of tumor-bearing animals by neutralization and IF techniques. Neither HSV-2 infectious virus nor viral antigens could be detected by the transfer of transformed-cell DNA into permissive cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0020-7136
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
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|
pubmed:volume |
16
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|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
526-38
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pubmed:dateRevised |
2007-7-24
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pubmed:meshHeading |
pubmed-meshheading:170223-Animals,
pubmed-meshheading:170223-Antibodies, Viral,
pubmed-meshheading:170223-Antibody Specificity,
pubmed-meshheading:170223-Antigens, Viral,
pubmed-meshheading:170223-Cell Line,
pubmed-meshheading:170223-Cell Transformation, Neoplastic,
pubmed-meshheading:170223-DNA, Neoplasm,
pubmed-meshheading:170223-DNA, Viral,
pubmed-meshheading:170223-Mice,
pubmed-meshheading:170223-Mice, Inbred BALB C,
pubmed-meshheading:170223-Neoplasm Transplantation,
pubmed-meshheading:170223-Neoplasms, Experimental,
pubmed-meshheading:170223-Neutralization Tests,
pubmed-meshheading:170223-Radiation Effects,
pubmed-meshheading:170223-Simplexvirus,
pubmed-meshheading:170223-Transplantation, Isogeneic,
pubmed-meshheading:170223-Ultraviolet Rays
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pubmed:year |
1975
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pubmed:articleTitle |
Transformation of mouse cells after infection with ultraviolet irradiation-inactivated herpes simplex virus type 2.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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