Source:http://linkedlifedata.com/resource/pubmed/id/17021767
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2006-11-19
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| pubmed:abstractText |
HLA complex is composed of several closely linked loci, each containing several alleles, yielding a high expression of polymorphism. Vitiligo, a commonly acquired dermatological disorder, has been associated with different HLA antigens in different ethnic groups. In this study, HLA classes I (HLA-A, B, and C) and II (HLA-DR, DQ) antigens/alleles were analyzed in a group of 80 Saudi subjects consisting of vitiligo patients (40) and matched controls (40). The frequency of antigens of various HLA loci was tested using two-stage microcytotoxicity assays, while the frequency of alleles of HLA-DR was screened by polymerase chain reaction/sequence specific primers (PCR/SSP) method. The frequencies of HLA-B7, B15, Bw6, Cw6, Cw7, and DRB4*010101 were found to be significantly higher in vitiligo patients compared to controls [P = 0.029, 0.015, 0.033, 0.009, 0.043, and 0.015, respectively, with relative risk (RR) > or = 3, etiologic fraction (EF) > or = 0.4]. On the other hand, HLA-A9, B5, DQ1, and DRB3*010101 were significantly decreased in vitiligo patients compared to healthy Saudis [P = 0.008, 0.004, 0.028, and 0.04, respectively, with RR < 1 and preventive fraction (PF) < 0.5]. Among the patients, the highest allele frequency was noted for DRB4*010101(70%), while in controls it was for DRB3*010101 (72.5%). These results for antigens and allele frequency of various HLA Loci in vitiligo patients and control subjects suggested that HLA-B7, Bw6, Cw6, Cw7, and DRB4*010101 could be susceptible to vitiligo, while HLA-A9, B5, DQ1, and DRB3*010101 might be negatively associated with the development of vitiligo in Saudis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B15 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-B7 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-Bw6 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-C*06 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-C*70 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-C Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB1 Chains,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DRB4*01:01 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II
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| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
|
| pubmed:issn |
0340-3696
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
298
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
347-52
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:17021767-Adolescent,
pubmed-meshheading:17021767-Adult,
pubmed-meshheading:17021767-Alleles,
pubmed-meshheading:17021767-Case-Control Studies,
pubmed-meshheading:17021767-Female,
pubmed-meshheading:17021767-Gene Frequency,
pubmed-meshheading:17021767-HLA-B Antigens,
pubmed-meshheading:17021767-HLA-B15 Antigen,
pubmed-meshheading:17021767-HLA-B7 Antigen,
pubmed-meshheading:17021767-HLA-C Antigens,
pubmed-meshheading:17021767-HLA-DR Antigens,
pubmed-meshheading:17021767-HLA-DRB1 Chains,
pubmed-meshheading:17021767-Histocompatibility Antigens Class I,
pubmed-meshheading:17021767-Histocompatibility Antigens Class II,
pubmed-meshheading:17021767-Humans,
pubmed-meshheading:17021767-Male,
pubmed-meshheading:17021767-Middle Aged,
pubmed-meshheading:17021767-Saudi Arabia,
pubmed-meshheading:17021767-Vitiligo
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| pubmed:year |
2006
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| pubmed:articleTitle |
Association of HLA loci alleles and antigens in Saudi patients with vitiligo.
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| pubmed:affiliation |
Department of Dermatology, Armed Forces Hospital, Riyadh 11159, Saudi Arabia.
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| pubmed:publicationType |
Journal Article
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