Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
40
pubmed:dateCreated
2006-10-5
pubmed:abstractText
The human amygdala has classically been viewed as a brain structure primarily related to emotions and dissociated from higher cognition. We report here findings suggesting that the human amygdala also has a role in supporting working memory (WM), a canonical higher cognitive function. In a first functional magnetic resonance imaging (fMRI) study (n = 53), individual differences in amygdala activity predicted behavioral performance in a 3-back WM task. Specifically, higher event-related amygdala amplitude predicted faster response time (RT; r = -0.64), with no loss of accuracy. This relationship was not contingent on mood state, task content, or personality variables. In a second fMRI study (n = 21), we replicated the key finding (r = -0.47) and further showed that the correlation between the amygdala and faster RT was specific to a high working memory load condition (3-back) compared with a low working memory load condition (1-back). These results support models of amygdala function that can account for its involvement not only in emotion but also higher cognition.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-10073923, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-10195224, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-10456071, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-11017179, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-11133316, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-11175882, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-11244481, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-11259662, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-11430815, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-11561919, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-11904454, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-12025764, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-12177449, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-12372290, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-12453496, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-12505650, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-12592404, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-12708528, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-12925284, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-12948724, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-14640318, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-15050566, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-15205883, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-15604401, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-15758155, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-15846822, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-16180624, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-16204201, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-16371950, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-16476670, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-16597732, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-2363833, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-2966230, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-6571423, http://linkedlifedata.com/resource/pubmed/commentcorrection/17021168-8893004
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
4
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
10120-8
pubmed:dateRevised
2010-9-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Individual differences in amygdala activity predict response speed during working memory.
pubmed:affiliation
Psychology Department, Yale University, New Haven, Connecticut 06520, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural