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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
49
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pubmed:dateCreated |
2006-12-6
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pubmed:abstractText |
A major class of disease-resistance (R) genes in plants encode nucleotide-binding site/leucine-rich repeat (LRR) proteins. The LRR domains mediate recognition of pathogen-derived elicitors. Here we describe a random in vitro mutation analysis illustrating how mutations in an R protein (Rx) LRR domain generate disease-resistance specificity. The original Rx protein confers resistance only against a subset of potato virus X (PVX) strains, whereas selected mutants were effective against an additional strain of PVX and against the distantly related poplar mosaic virus. These effects of LRR mutations indicate that in vitro evolution of R genes could be exploited for enhancement of disease resistance in crop plants. Our results also illustrate how short-term evolution of disease resistance in wild populations might be toward broader spectrum resistance against multiple strains of the pathogen. The breadth of the disease-resistance phenotype from a natural R gene may be influenced by the tradeoff between the costs and benefits of broad-spectrum disease resistance.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-10072407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-10330465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-10554774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-10631483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-10652152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-11050946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-11121079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-11158537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-11194869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-11459065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-11844114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-11874570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-11967365,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-12147768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-12198153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-12383085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-12417711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-12581527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-12615945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-12721627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-12787241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-14592968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-14726927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-14973158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-15012507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-15044951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-15082565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-15155876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-15208416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-15231261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-15361584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-15591208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-15806097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-1629709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-16786290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-2744488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-7599646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-8212565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-8580963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-8710948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-9533877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-9724691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17021014-9868361
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
18828-33
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pubmed:dateRevised |
2010-9-15
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pubmed:meshHeading |
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pubmed:year |
2006
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pubmed:articleTitle |
Artificial evolution extends the spectrum of viruses that are targeted by a disease-resistance gene from potato.
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pubmed:affiliation |
The Sainsbury Laboratory, John Innes Centre, Norwich NR4 7UH, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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