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rdf:type |
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lifeskim:mentions |
umls-concept:C0001483,
umls-concept:C0007102,
umls-concept:C0332466,
umls-concept:C0333467,
umls-concept:C0334227,
umls-concept:C0442805,
umls-concept:C1332402,
umls-concept:C1514562,
umls-concept:C1518581,
umls-concept:C1521840,
umls-concept:C1709313,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:dateCreated |
2006-10-16
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pubmed:abstractText |
The Wnt signaling pathway is activated by mutations in the APC and beta-catenin genes in many types of human cancer. beta-catenin is stabilized by these mutations and activates transcription in part by acting as a bridge between Tcf/LEF proteins and the HD2 domain of the BCL9 coactivator. We have previously described oncolytic adenoviruses with binding sites for Tcf/LEF transcription factors inserted into the early viral promoters. These viruses replicate selectively in cells with activation of the Wnt pathway. To increase the activity of these viruses we have fused the viral transactivator E1A to the BCL9 HD2 domain.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-10353252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-10516724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-10700188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-10775268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-10980707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-10984057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-11035789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-11050151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-11222711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-11834740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-11896466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-11955446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-11988739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-12015286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-12134001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-12163411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-12186902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-12223464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-12606575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-12684397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-12712206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-12781368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-15001769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-15208637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-15492040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-16061672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-2139141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-2975755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-6310869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-6334304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-7758944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-8417352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-8788172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-9205061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-9363682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-9501980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-975046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-9891778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17020613-9990852
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2407
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
236
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17020613-Adenovirus E1A Proteins,
pubmed-meshheading:17020613-Animals,
pubmed-meshheading:17020613-Cell Line, Tumor,
pubmed-meshheading:17020613-Colonic Neoplasms,
pubmed-meshheading:17020613-Cytopathogenic Effect, Viral,
pubmed-meshheading:17020613-Female,
pubmed-meshheading:17020613-Gene Fusion,
pubmed-meshheading:17020613-HeLa Cells,
pubmed-meshheading:17020613-Humans,
pubmed-meshheading:17020613-Mice,
pubmed-meshheading:17020613-Mice, Nude,
pubmed-meshheading:17020613-Neoplasm Proteins,
pubmed-meshheading:17020613-Oncolytic Viruses,
pubmed-meshheading:17020613-Signal Transduction,
pubmed-meshheading:17020613-Wnt Proteins,
pubmed-meshheading:17020613-Xenograft Model Antitumor Assays,
pubmed-meshheading:17020613-beta Catenin
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pubmed:year |
2006
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pubmed:articleTitle |
Fusion of the BCL9 HD2 domain to E1A increases the cytopathic effect of an oncolytic adenovirus that targets colon cancer cells.
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pubmed:affiliation |
NCCR Molecular Oncology Programme, Swiss Institute for Experimental Cancer Research (ISREC), Epalinges, Switzerland. cfuerer@stanford.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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