Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
1991-1-29
|
| pubmed:abstractText |
In the hematopoietic system, the B-cell associated antigen CD24 is expressed at high density on B cells, B-cell precursors, and B-cell malignancies as well as at low density on peripheral blood polymorphonuclear leukocytes. The 42-Kd sialoglycoprotein has not been previously demonstrated to be expressed on T cells, thymocytes, or T-cell malignancies. We identified three patients with mycosis fungoides/Sézary syndrome that showed low density expression of the CD24-related epitope recognized by antibody BA-1 on circulating T cells. All three patients had Sézary cells by morphologic assessment and clonal T-cell populations in the peripheral blood by gene rearrangement studies. In two of these patients, indirect immunofluorescence with a panel of six anti-CD24 monoclonal antibodies demonstrated reactivity for two of six antibodies in one case and only one of six antibodies in the other. The biologic significance of CD24-related epitope expression on circulating T cells in mycosis fungoides/Sézary syndrome is unclear. However, these findings suggest that differential, low density expression of CD24-related epitopes (BA-1+, OKB2-) may be a useful phenotypic marker for identifying circulating Sézary cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD24,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CD24 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
76
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2343-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1701668-Antibodies, Monoclonal,
pubmed-meshheading:1701668-Antigens, CD,
pubmed-meshheading:1701668-Antigens, CD24,
pubmed-meshheading:1701668-Antigens, Differentiation,
pubmed-meshheading:1701668-Epitopes,
pubmed-meshheading:1701668-Female,
pubmed-meshheading:1701668-Fluorescent Antibody Technique,
pubmed-meshheading:1701668-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:1701668-Humans,
pubmed-meshheading:1701668-Immunophenotyping,
pubmed-meshheading:1701668-Male,
pubmed-meshheading:1701668-Membrane Glycoproteins,
pubmed-meshheading:1701668-Middle Aged,
pubmed-meshheading:1701668-Mycosis Fungoides,
pubmed-meshheading:1701668-Sezary Syndrome,
pubmed-meshheading:1701668-Skin Neoplasms,
pubmed-meshheading:1701668-T-Lymphocytes,
pubmed-meshheading:1701668-Tumor Markers, Biological
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Differential expression of CD24-related epitopes in mycosis fungoides/Sézary syndrome: a potential marker for circulating Sézary cells.
|
| pubmed:affiliation |
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68105-1065.
|
| pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|