Protease-activated receptor type 1 (PAR-1) has been proposed as the principal thrombin receptor in humans, although its actions in vivo have not been defined. The aim of the present study was to determine the direct vascular actions of PAR-1 agonism in humans.
Centre for Cardiovascular Science, University of Edinburgh, Royal Infirmary, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. Ingibjorg.Gudmunds@ed.ac.uk