Linked Life Data

17014841

Source:http://linkedlifedata.com/resource/pubmed/id/17014841

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-1-22
pubmed:abstractText
Fibroblast growth factor 18 (FGF18) has been shown to regulate chondrocyte proliferation and differentiation by signaling through FGF receptor 3 (FGFR3) and to regulate osteogenesis by signaling through other FGFRs. Fgf18(-/-) mice have an apparent delay in skeletal mineralization that is not seen in Fgfr3(-/-) mice. However, this delay in mineralization could not be simply explained by FGF18 signaling to osteoblasts. Here we show that delayed mineralization in Fgf18(-/-) mice was closely associated with delayed initiation of chondrocyte hypertrophy, decreased proliferation at early stages of chondrogenesis, delayed skeletal vascularization and delayed osteoclast and osteoblast recruitment to the growth plate. We further show that FGF18 is necessary for Vegf expression in hypertrophic chondrocytes and the perichondrium and is sufficient to induce Vegf expression in skeletal explants. These findings support a model in which FGF18 regulates skeletal vascularization and subsequent recruitment of osteoblasts/osteoclasts through regulation of early stages of chondrogenesis and VEGF expression. FGF18 thus coordinates neovascularization of the growth plate with chondrocyte and osteoblast growth and differentiation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
302
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
80-91
pubmed:dateRevised
2011-4-29
pubmed:meshHeading
pubmed-meshheading:17014841-Animals, pubmed-meshheading:17014841-Cell Proliferation, pubmed-meshheading:17014841-Chondrocytes, pubmed-meshheading:17014841-Chondrogenesis, pubmed-meshheading:17014841-Embryo, Mammalian, pubmed-meshheading:17014841-Extremities, pubmed-meshheading:17014841-Fibroblast Growth Factors, pubmed-meshheading:17014841-Gene Expression Regulation, Developmental, pubmed-meshheading:17014841-Growth Plate, pubmed-meshheading:17014841-Lac Operon, pubmed-meshheading:17014841-Mice, pubmed-meshheading:17014841-Neovascularization, Physiologic, pubmed-meshheading:17014841-Osteoblasts, pubmed-meshheading:17014841-Osteoclasts, pubmed-meshheading:17014841-Osteogenesis, pubmed-meshheading:17014841-Receptors, Vascular Endothelial Growth Factor, pubmed-meshheading:17014841-Vascular Endothelial Growth Factor A
pubmed:year
2007
pubmed:articleTitle
FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate.
pubmed:affiliation
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural