Source:http://linkedlifedata.com/resource/pubmed/id/17013381
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2006-12-6
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| pubmed:abstractText |
The mechanisms by which active neurons, via astrocytes, rapidly signal intracerebral arterioles to dilate remain obscure. Here we show that modest elevation of extracellular potassium (K+) activated inward rectifier K+ (Kir) channels and caused membrane potential hyperpolarization in smooth muscle cells (SMCs) of intracerebral arterioles and, in cortical brain slices, induced Kir-dependent vasodilation and suppression of SMC intracellular calcium (Ca2+) oscillations. Neuronal activation induced a rapid (<2 s latency) vasodilation that was greatly reduced by Kir channel blockade and completely abrogated by concurrent cyclooxygenase inhibition. Astrocytic endfeet exhibited large-conductance, Ca2+-sensitive K+ (BK) channel currents that could be activated by neuronal stimulation. Blocking BK channels or ablating the gene encoding these channels prevented neuronally induced vasodilation and suppression of arteriolar SMC Ca2+, without affecting the astrocytic Ca2+ elevation. These results support the concept of intercellular K+ channel-to-K+ channel signaling, through which neuronal activity in the form of an astrocytic Ca2+ signal is decoded by astrocytic BK channels, which locally release K+ into the perivascular space to activate SMC Kir channels and cause vasodilation.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1097-6256
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
9
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1397-1403
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| pubmed:dateRevised |
2007-12-3
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| pubmed:meshHeading |
pubmed-meshheading:17013381-Animals,
pubmed-meshheading:17013381-Arterioles,
pubmed-meshheading:17013381-Astrocytes,
pubmed-meshheading:17013381-Brain,
pubmed-meshheading:17013381-Calcium,
pubmed-meshheading:17013381-Cerebrovascular Circulation,
pubmed-meshheading:17013381-Electric Stimulation,
pubmed-meshheading:17013381-Electrophysiology,
pubmed-meshheading:17013381-Male,
pubmed-meshheading:17013381-Membrane Potentials,
pubmed-meshheading:17013381-Muscle, Smooth, Vascular,
pubmed-meshheading:17013381-Neurons,
pubmed-meshheading:17013381-Patch-Clamp Techniques,
pubmed-meshheading:17013381-Potassium,
pubmed-meshheading:17013381-Potassium Channels, Inwardly Rectifying,
pubmed-meshheading:17013381-Rats,
pubmed-meshheading:17013381-Rats, Sprague-Dawley,
pubmed-meshheading:17013381-Signal Transduction,
pubmed-meshheading:17013381-Vasodilation
|
| pubmed:year |
2006
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| pubmed:articleTitle |
Local potassium signaling couples neuronal activity to vasodilation in the brain.
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| pubmed:affiliation |
Department of Pharmacology, 89 Beaumont Avenue, College of Medicine, University of Vermont, Burlington, Vermont 05405, USA.
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| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|