| pubmed-article:1701231 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1701231 | lifeskim:mentions | umls-concept:C0023467 | lld:lifeskim |
| pubmed-article:1701231 | lifeskim:mentions | umls-concept:C0008659 | lld:lifeskim |
| pubmed-article:1701231 | lifeskim:mentions | umls-concept:C1283195 | lld:lifeskim |
| pubmed-article:1701231 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:1701231 | pubmed:dateCreated | 1991-1-16 | lld:pubmed |
| pubmed-article:1701231 | pubmed:abstractText | The 17q11-21 chromosomal region is frequently involved in non-random structural rearrangements associated with the M1 and M2 subtypes of acute myeloid leukemias (AML), as well as with the 15;17 translocation typical of the promyelocytic subtype. A number of genes have been localized in this region including the c-erbA-1 and c-erbB-2 proto-oncogenes, the genes coding for the granulocyte-colony stimulating factor (G-CSF), the retinoic acid receptor alpha (RAR alpha) and the myeloperoxidase enzyme (MPO). However, the precise location of these genes in relationship to the 17q11-21 breakpoint(s) has not been determined. Using in situ hybridization on metaphase chromosomes, we established the position of the breakpoints in relationship to the c-erbA-1, c-erbB-2, G-CSF, RAR alpha and MPO loci in a series of AML cases bearing 17q11-21 rearrangements. We report: (i) that the respective position of the five genes is centromere - c-erbA-1 - G-CSF - c-erbB-2 - RAR alpha - MPO - telomere; (ii) that the breakpoints of the various AML subtypes are variably located between the centromere and c-erbB-2 in M1 and M2; (iii) that the breakpoints are consistently located between c-erbB-2 and RAR alpha/MPO in M3; and (iv) that the breakpoint on chromosome 17 in the 15;17 translocation is located on 17q21 and not on 17q11-12 as previously reported. | lld:pubmed |
| pubmed-article:1701231 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1701231 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1701231 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1701231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1701231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1701231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1701231 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1701231 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1701231 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1701231 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:1701231 | pubmed:author | pubmed-author:LongoLL | lld:pubmed |
| pubmed-article:1701231 | pubmed:author | pubmed-author:AvanziGG | lld:pubmed |
| pubmed-article:1701231 | pubmed:author | pubmed-author:AlimenaGG | lld:pubmed |
| pubmed-article:1701231 | pubmed:author | pubmed-author:GrignaniFF | lld:pubmed |
| pubmed-article:1701231 | pubmed:author | pubmed-author:PegoraroLL | lld:pubmed |
| pubmed-article:1701231 | pubmed:author | pubmed-author:DontiEE | lld:pubmed |
| pubmed-article:1701231 | pubmed:author | pubmed-author:VentiGG | lld:pubmed |
| pubmed-article:1701231 | pubmed:author | pubmed-author:PelicciP GPG | lld:pubmed |
| pubmed-article:1701231 | pubmed:author | pubmed-author:MencarelliAA | lld:pubmed |
| pubmed-article:1701231 | pubmed:author | pubmed-author:TabilioAA | lld:pubmed |
| pubmed-article:1701231 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1701231 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:1701231 | pubmed:geneSymbol | c-erbB-2 | lld:pubmed |
| pubmed-article:1701231 | pubmed:geneSymbol | c-erbB-1 | lld:pubmed |
| pubmed-article:1701231 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1701231 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1701231 | pubmed:pagination | 1557-63 | lld:pubmed |
| pubmed-article:1701231 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:meshHeading | pubmed-meshheading:1701231-... | lld:pubmed |
| pubmed-article:1701231 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1701231 | pubmed:articleTitle | Mapping of chromosome 17 breakpoints in acute myeloid leukemias. | lld:pubmed |
| pubmed-article:1701231 | pubmed:affiliation | Istituto di Clinica Medica I, University of Perugia, Policlinico Monteluce, Italy. | lld:pubmed |
| pubmed-article:1701231 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1701231 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1701231 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1701231 | lld:pubmed |
