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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1991-1-16
|
| pubmed:abstractText |
The 17q11-21 chromosomal region is frequently involved in non-random structural rearrangements associated with the M1 and M2 subtypes of acute myeloid leukemias (AML), as well as with the 15;17 translocation typical of the promyelocytic subtype. A number of genes have been localized in this region including the c-erbA-1 and c-erbB-2 proto-oncogenes, the genes coding for the granulocyte-colony stimulating factor (G-CSF), the retinoic acid receptor alpha (RAR alpha) and the myeloperoxidase enzyme (MPO). However, the precise location of these genes in relationship to the 17q11-21 breakpoint(s) has not been determined. Using in situ hybridization on metaphase chromosomes, we established the position of the breakpoints in relationship to the c-erbA-1, c-erbB-2, G-CSF, RAR alpha and MPO loci in a series of AML cases bearing 17q11-21 rearrangements. We report: (i) that the respective position of the five genes is centromere - c-erbA-1 - G-CSF - c-erbB-2 - RAR alpha - MPO - telomere; (ii) that the breakpoints of the various AML subtypes are variably located between the centromere and c-erbB-2 in M1 and M2; (iii) that the breakpoints are consistently located between c-erbB-2 and RAR alpha/MPO in M3; and (iv) that the breakpoint on chromosome 17 in the 15;17 translocation is located on 17q21 and not on 17q11-12 as previously reported.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Granulocyte Colony-Stimulating...,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thyroid Hormone
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0950-9232
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:geneSymbol |
c-erbB-1,
c-erbB-2
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1557-63
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:1701231-Acute Disease,
pubmed-meshheading:1701231-Bone Marrow,
pubmed-meshheading:1701231-Cell Line,
pubmed-meshheading:1701231-Chromosome Banding,
pubmed-meshheading:1701231-Chromosome Deletion,
pubmed-meshheading:1701231-Chromosome Mapping,
pubmed-meshheading:1701231-Chromosomes, Human, Pair 17,
pubmed-meshheading:1701231-Female,
pubmed-meshheading:1701231-Gene Rearrangement,
pubmed-meshheading:1701231-Granulocyte Colony-Stimulating Factor,
pubmed-meshheading:1701231-Humans,
pubmed-meshheading:1701231-Karyotyping,
pubmed-meshheading:1701231-Leukemia, Myeloid,
pubmed-meshheading:1701231-Male,
pubmed-meshheading:1701231-Nucleic Acid Hybridization,
pubmed-meshheading:1701231-Proto-Oncogene Proteins,
pubmed-meshheading:1701231-Proto-Oncogenes,
pubmed-meshheading:1701231-Receptor, erbB-2,
pubmed-meshheading:1701231-Receptors, Thyroid Hormone
|
| pubmed:year |
1990
|
| pubmed:articleTitle |
Mapping of chromosome 17 breakpoints in acute myeloid leukemias.
|
| pubmed:affiliation |
Istituto di Clinica Medica I, University of Perugia, Policlinico Monteluce, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|