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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2006-11-20
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pubmed:abstractText |
The purpose of this study was to examine the distribution of brevetoxin-3 administered to pregnant dams and to determine the extent of placental transport to fetuses. Twenty-nine pregnant CD-1 mice were administered (3)H-brevetoxin-3 ( approximately 1.3 microCi/animal; approximately 2.8 microg compound/kg) by intratracheal instillation on one of gestational days 15-18. Groups of four or five dams were killed at selected times through 48 h post-dosing. Four pregnant dams were administered (3)H-brevetoxin-3 on gestational day 15 or 16 via osmotic minipump to provide continuous delivery of compound ( approximately 0.13 microCi, 7.5 ng compound/day) over a 72-h period. Then the dams and fetuses were killed. Brevetoxin-associated radioactivity was detected in placentas and fetuses within 0.5h of intratracheal administration. Concentrations of brevetoxin equivalents in fetuses were approximately 0.3 ng/g throughout the 48-h post-dosing, resulting in a calculated dose to fetuses of 19 ng/gh. Following brevetoxin infusion, concentration of brevetoxin equivalents in fetuses was 0.1 ng/g, lower than that present in most maternal tissues. Results demonstrated placental transport of brevetoxin or its metabolites following maternal acute exposure and repeated low-dose exposure. The consequences of these findings for pregnant women exposed to brevetoxins by inhalation or ingestion remain to be determined.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-10346993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-10405188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-10728835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-10852846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-11335186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-11836147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-12151632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-12527696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-12842779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-12842781,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-14965250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-14965255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-15371231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-15447946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-15866773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-15866775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-15866776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-15866777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-15866778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-15866779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-15986201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-16059676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-16760139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-2080516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-2426567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-2565840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-6891120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-8310449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-8549497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-9363372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-9493316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011606-9653056
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0041-0101
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1018-26
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17011606-Animals,
pubmed-meshheading:17011606-Biological Transport,
pubmed-meshheading:17011606-Female,
pubmed-meshheading:17011606-Fetus,
pubmed-meshheading:17011606-Marine Toxins,
pubmed-meshheading:17011606-Maternal-Fetal Exchange,
pubmed-meshheading:17011606-Mice,
pubmed-meshheading:17011606-Mice, Inbred Strains,
pubmed-meshheading:17011606-Oxocins,
pubmed-meshheading:17011606-Placenta,
pubmed-meshheading:17011606-Pregnancy
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pubmed:year |
2006
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pubmed:articleTitle |
Placental transport of brevetoxin-3 in CD-1 mice.
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pubmed:affiliation |
Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE., Albuquerque NM 87108, USA. jbenson@LRRI.org
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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