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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-11-10
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pubmed:abstractText |
LINGO-1 is a CNS-specific protein and a functional component of the NgR1/p75/LINGO-1 and NgR1/TAJ(TROY)/LINGO-1 signaling complexes that mediate inhibition of axonal outgrowth. These receptor complexes mediate the axonal growth inhibitory effects of Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte-myelin glycoprotein (OMgp) via RhoA activation. Soluble LINGO-1 (LINGO-1-Fc), which acts as an antagonist of these pathways by blocking LINGO-1 binding to NgR1, was administered to rats after dorsal or lateral hemisection of the spinal cord. LINGO-1-Fc treatment significantly improved functional recovery, promoted axonal sprouting and decreased RhoA activation and increased oligodendrocyte and neuronal survival after either rubrospinal or corticospinal tract transection. These experiments demonstrate an important role for LINGO-1 in modulating axonal outgrowth in vivo and that treatment with LINGO-1-Fc can significantly enhance recovery after spinal cord injury.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/LINGO1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tubulin,
http://linkedlifedata.com/resource/pubmed/chemical/beta3 tubulin, rat,
http://linkedlifedata.com/resource/pubmed/chemical/rhoA GTP-Binding Protein
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1044-7431
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pubmed:author |
pubmed-author:JiBenxiuB,
pubmed-author:LeeXinhuaX,
pubmed-author:LiMingweiM,
pubmed-author:McCoyJohn MJM,
pubmed-author:PepinskyR BlakeRB,
pubmed-author:ReltonJane KJK,
pubmed-author:ShaoZhaohuiZ,
pubmed-author:SoKwok-FaiKF,
pubmed-author:UsaSS,
pubmed-author:WangJoyJ,
pubmed-author:WuWu-TianWT,
pubmed-author:YickLeung-WahLW
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
311-20
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pubmed:dateRevised |
2011-6-29
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pubmed:meshHeading |
pubmed-meshheading:17011208-Analysis of Variance,
pubmed-meshheading:17011208-Animals,
pubmed-meshheading:17011208-Apoptosis,
pubmed-meshheading:17011208-Axons,
pubmed-meshheading:17011208-Caspase 3,
pubmed-meshheading:17011208-Disease Models, Animal,
pubmed-meshheading:17011208-Dose-Response Relationship, Drug,
pubmed-meshheading:17011208-Forelimb,
pubmed-meshheading:17011208-Humans,
pubmed-meshheading:17011208-Immunohistochemistry,
pubmed-meshheading:17011208-In Situ Nick-End Labeling,
pubmed-meshheading:17011208-MAP Kinase Kinase 4,
pubmed-meshheading:17011208-Membrane Proteins,
pubmed-meshheading:17011208-Nerve Regeneration,
pubmed-meshheading:17011208-Nerve Tissue Proteins,
pubmed-meshheading:17011208-Organogenesis,
pubmed-meshheading:17011208-Protein Binding,
pubmed-meshheading:17011208-RNA-Binding Proteins,
pubmed-meshheading:17011208-Rats,
pubmed-meshheading:17011208-Rats, Sprague-Dawley,
pubmed-meshheading:17011208-Recombinant Fusion Proteins,
pubmed-meshheading:17011208-Recovery of Function,
pubmed-meshheading:17011208-Spinal Cord Injuries,
pubmed-meshheading:17011208-Time Factors,
pubmed-meshheading:17011208-Tubulin,
pubmed-meshheading:17011208-rhoA GTP-Binding Protein
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pubmed:year |
2006
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pubmed:articleTitle |
LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury.
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pubmed:affiliation |
Biogen Idec, Inc., 14 Cambridge Center, Cambridge, MA 02142, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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