Linked Life Data

17011204

Source:http://linkedlifedata.com/resource/pubmed/id/17011204

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-11-24
pubmed:abstractText
This study sought to determine the role of the transcription factor E2F1 in CXCR4-mediated neurotoxicity and HIV neuropathology. We studied the effect of the HIV envelope protein gp120 on the expression of E2F1-dependent apoptotic proteins in human and rodent neurons and examined the expression pattern of E2F1 in the brain of HIV-infected individuals. Our findings suggest that in cultured neurons gp120 increased E2F1 levels in the nucleus, stimulated its transcriptional activity and enhanced the expression of the E2F1 target proteins Cdc2 and Puma. Studies with neuronal cultures from E2F1 deficient mice demonstrated that the transcription factor is required for gp120-induced neurotoxicity and up-regulation of Cdc2 and Puma. Levels of E2F1 protein were greater in the nucleus of neurons in brains of HIV-infected patients exhibiting dementia when compared to HIV-negative subjects or HIV-positive neurologically normal patients. Overall, these studies indicate that E2F1 is primarily involved in CXCR4-mediated neurotoxicity and HIV neuropathogenesis.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/DA 19808, http://linkedlifedata.com/resource/pubmed/grant/DA15014, http://linkedlifedata.com/resource/pubmed/grant/MH59724, http://linkedlifedata.com/resource/pubmed/grant/MH59745-06, http://linkedlifedata.com/resource/pubmed/grant/N01MH32002, http://linkedlifedata.com/resource/pubmed/grant/NS 41561, http://linkedlifedata.com/resource/pubmed/grant/NS38841, http://linkedlifedata.com/resource/pubmed/grant/NS45491, http://linkedlifedata.com/resource/pubmed/grant/R01 DA015014-03, http://linkedlifedata.com/resource/pubmed/grant/R01 DA015014-04, http://linkedlifedata.com/resource/pubmed/grant/R01 DA015014-05, http://linkedlifedata.com/resource/pubmed/grant/R01 DA019808-01, http://linkedlifedata.com/resource/pubmed/grant/R01 DA019808-02, http://linkedlifedata.com/resource/pubmed/grant/R01 DA019808-03
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-10077639, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-10219738, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-10393974, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-10545779, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-10871762, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-11532163, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-11896158, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-11935459, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-12034737, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-12049737, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-12101227, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-12145207, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-12629169, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-12707851, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-12743233, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-12759259, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-12775414, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-12778117, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-12907388, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-14605830, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-14684737, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-15155568, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-15630430, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-15638723, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-15708626, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-15761472, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-15939925, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-16005638, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-16127150, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-16276420, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-16298136, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-6467378, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-7477730, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-7747806, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-7935380, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-8248803, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-8653790, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-8903316, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-9207076, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-9601645, http://linkedlifedata.com/resource/pubmed/commentcorrection/17011204-9826729
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0969-9961
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
17-26
pubmed:dateRevised
2011-8-1
pubmed:meshHeading
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