Source:http://linkedlifedata.com/resource/pubmed/id/17010616
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2006-11-20
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pubmed:abstractText |
Bisnaphthalimidopropyl derivatives (BNIPSpd, BNIPDaoct, BNIPDanon, BNIPDadec, BNIPDpta and BNIPDeta) were synthesised in yields ranging from 50% to 70% and their cytotoxicity against colon cancer cells (Caco-2) and the parasite Leishmania infantum determined using the MTT assay. Cytotoxicity within Caco-2 cells was manifested with IC(50) values between 0.3 and 22 microM. Compounds with the central longer alkyl chains exhibited the highest cytotoxicity. Against L. infantum, IC(50) values were encompassed within a narrower concentration range of 0.47-1.54 microM. In the parasites, the presence of nitrogen in the central chain and the length of the central alkyl chains did not especially enhance cytotoxicity. This may be due to the way these compounds are transported in the cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0968-0896
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
541-5
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pubmed:meshHeading |
pubmed-meshheading:17010616-Animals,
pubmed-meshheading:17010616-Antineoplastic Agents,
pubmed-meshheading:17010616-Antiparasitic Agents,
pubmed-meshheading:17010616-Caco-2 Cells,
pubmed-meshheading:17010616-Cell Proliferation,
pubmed-meshheading:17010616-Colonic Neoplasms,
pubmed-meshheading:17010616-Drug Screening Assays, Antitumor,
pubmed-meshheading:17010616-Humans,
pubmed-meshheading:17010616-Leishmania infantum,
pubmed-meshheading:17010616-Molecular Structure,
pubmed-meshheading:17010616-Parasitic Sensitivity Tests,
pubmed-meshheading:17010616-Polyamines,
pubmed-meshheading:17010616-Stereoisomerism,
pubmed-meshheading:17010616-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
The synthesis and the in vitro cytotoxicity studies of bisnaphthalimidopropyl polyamine derivatives against colon cancer cells and parasite Leishmania infantum.
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pubmed:affiliation |
The Robert Gordon University, School of Life Sciences, St. Andrew Street, Aberdeen AB25 1HG, Scotland, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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