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rdf:type |
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lifeskim:mentions |
umls-concept:C0001962,
umls-concept:C0012634,
umls-concept:C0025914,
umls-concept:C0026336,
umls-concept:C0026809,
umls-concept:C0079809,
umls-concept:C0242485,
umls-concept:C0243067,
umls-concept:C0442027,
umls-concept:C0521457,
umls-concept:C1280500,
umls-concept:C1299003,
umls-concept:C1512806,
umls-concept:C1858460,
umls-concept:C2827424
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pubmed:issue |
10
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pubmed:dateCreated |
2006-10-2
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pubmed:abstractText |
This work was conducted in an effort to establish an oral intake model system in which the effects of ethanol insult that occur during early stages of embryogenesis can be easily examined and in which agents that may modulate ethanol's teratogenicity can be readily tested in vivo. The model system described utilizes the alcohol deprivation effect to obtain teratogenic levels of maternal ethanol intake on days 7 and 8 of pregnancy in C57Bl/6J mice. Ocular defects including microphthalmia and uveal coloboma, which have previously been shown to result from ethanol administered by gavage or via intraperitoneal injection on these days, served as the developmental end point for this study. The ocular defects are readily identifiable and their degree of severity is expected to correlate with concurrently developing defects of the central nervous system (CNS).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0145-6008
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1791-8
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17010146-Abnormalities, Drug-Induced,
pubmed-meshheading:17010146-Animals,
pubmed-meshheading:17010146-Central Nervous System,
pubmed-meshheading:17010146-Central Nervous System Depressants,
pubmed-meshheading:17010146-Disease Models, Animal,
pubmed-meshheading:17010146-Embryonic Development,
pubmed-meshheading:17010146-Ethanol,
pubmed-meshheading:17010146-Eye,
pubmed-meshheading:17010146-Eye Abnormalities,
pubmed-meshheading:17010146-Female,
pubmed-meshheading:17010146-Fetal Alcohol Syndrome,
pubmed-meshheading:17010146-Fetal Development,
pubmed-meshheading:17010146-Gastrula,
pubmed-meshheading:17010146-Incidence,
pubmed-meshheading:17010146-Mice,
pubmed-meshheading:17010146-Mice, Inbred C57BL,
pubmed-meshheading:17010146-Pregnancy,
pubmed-meshheading:17010146-Prenatal Exposure Delayed Effects
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pubmed:year |
2006
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pubmed:articleTitle |
Maternal oral intake mouse model for fetal alcohol spectrum disorders: ocular defects as a measure of effect.
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pubmed:affiliation |
Bowles Center for Alcohol Studies, Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA. sparnell@med.unc.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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