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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2006-12-21
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pubmed:abstractText |
Cellular FLICE inhibitory protein--long form (c-FLIP(L)) is a caspase-defective homologue of caspase-8 that blocks apoptosis by death receptors. c-FLIP(L) expression in T cells can also augment activation of the mitogen-activated protein kinase, extracellular signal-related kinase, as well as nuclear factor-kappaB. This contributes to increased production of interleukin-2 and CD25, resulting in hyperproliferation of T cells from c-FLIP(L)-transgenic mice. c-FLIP also heterodimerizes with and activates caspase-8, resulting in increased death of T cells and a selection of a T helper 2 cytokine profile. The effects of c-FLIP on cytolytic function of CD8(+) T cells have not been examined previously. We studied the cytolytic capacity of T cells from c-FLIP(L)-transgenic mice using an antigen-specific system, as well as the consequences during a viral immune response to Coxsackievirus B3 (CVB3). The increased T-cell receptor (TCR) signalling due to c-FLIP did not alter the cytolytic machinery but did reduce cytotoxicity because of decreased surface expression of TCR and CD8. It also produced a Tc2 cytokine profile. These effects of c-FLIP collectively served to diminish the severity of CVB3-induced myocarditis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17010108-10837247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17010108-10894163,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/17010108-9794838
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
541-50
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17010108-Animals,
pubmed-meshheading:17010108-Antigens, CD8,
pubmed-meshheading:17010108-CASP8 and FADD-Like Apoptosis Regulating Protein,
pubmed-meshheading:17010108-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17010108-Cells, Cultured,
pubmed-meshheading:17010108-Coxsackievirus Infections,
pubmed-meshheading:17010108-Cytotoxicity, Immunologic,
pubmed-meshheading:17010108-Enterovirus B, Human,
pubmed-meshheading:17010108-Lymphocyte Activation,
pubmed-meshheading:17010108-Male,
pubmed-meshheading:17010108-Mice,
pubmed-meshheading:17010108-Mice, Inbred C57BL,
pubmed-meshheading:17010108-Mice, Transgenic,
pubmed-meshheading:17010108-Myocarditis,
pubmed-meshheading:17010108-Receptors, Antigen, T-Cell
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pubmed:year |
2006
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pubmed:articleTitle |
Reduced myocarditis following Coxsackievirus infection in cellular FLICE inhibitory protein--long form-transgenic mice.
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pubmed:affiliation |
Department of Pathology, The University of Vermont College of Medcine, Burlington, VT, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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