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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
37
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pubmed:dateCreated |
2006-9-29
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pubmed:abstractText |
Disabled-2 (DAB2) is a candidate tumor-suppressor gene identified in ovarian cancer that negatively influences mitogenic signal transduction of growth factors and blocks ras activity. In a recent study, we observed down-regulation of DAB2 transcripts in ESCCs using cDNA microarrays. In the present study, we aimed to determine the clinical significance of loss of DAB2 protein in esophageal tumorigenesis, hypothesizing that DAB2 promoter hypermethylation-mediated gene silencing may account for loss of the protein.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1007-9327
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6041-5
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pubmed:meshHeading |
pubmed-meshheading:17009406-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:17009406-Adult,
pubmed-meshheading:17009406-Carcinoma, Squamous Cell,
pubmed-meshheading:17009406-Cell Transformation, Neoplastic,
pubmed-meshheading:17009406-DNA, Neoplasm,
pubmed-meshheading:17009406-DNA Methylation,
pubmed-meshheading:17009406-Down-Regulation,
pubmed-meshheading:17009406-Esophageal Neoplasms,
pubmed-meshheading:17009406-Esophagus,
pubmed-meshheading:17009406-Exons,
pubmed-meshheading:17009406-Female,
pubmed-meshheading:17009406-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17009406-Humans,
pubmed-meshheading:17009406-Hyperplasia,
pubmed-meshheading:17009406-Immunohistochemistry,
pubmed-meshheading:17009406-Male,
pubmed-meshheading:17009406-Middle Aged,
pubmed-meshheading:17009406-Oligonucleotide Array Sequence Analysis
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pubmed:year |
2006
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pubmed:articleTitle |
Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis.
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pubmed:affiliation |
Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.
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pubmed:publicationType |
Journal Article
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