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pubmed-article:17008930pubmed:abstractTextTrypanosomes use RNA editing to produce most functional mitochondrial messenger RNA. Precise insertion and deletion of hundreds of uridines is necessary to make full-length cytochrome c oxidase III (COXIII) mRNA. We show that COXIII mRNA can be alternatively edited by a mechanism using an alternative guide RNA to make a stable mRNA. This alternatively edited mRNA is translated to produce a unique protein that fractionates with mitochondrial membranes and colocalizes with mitochondrial proteins in situ. Alternative RNA editing represents a previously unknown mechanism generating protein diversity and, as such, represents an important function for RNA editing.lld:pubmed
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pubmed-article:17008930pubmed:articleTitleAlternative editing of cytochrome c oxidase III mRNA in trypanosome mitochondria generates protein diversity.lld:pubmed
pubmed-article:17008930pubmed:affiliationProgram in Global Infectious Diseases, Josephine Bay Paul Center, Marine Biological Laboratory, 7 MBL Street, Woods Hole, Massachusetts 02543, USA.lld:pubmed
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