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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-11-1
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pubmed:abstractText |
Trypanosomes use RNA editing to produce most functional mitochondrial messenger RNA. Precise insertion and deletion of hundreds of uridines is necessary to make full-length cytochrome c oxidase III (COXIII) mRNA. We show that COXIII mRNA can be alternatively edited by a mechanism using an alternative guide RNA to make a stable mRNA. This alternatively edited mRNA is translated to produce a unique protein that fractionates with mitochondrial membranes and colocalizes with mitochondrial proteins in situ. Alternative RNA editing represents a previously unknown mechanism generating protein diversity and, as such, represents an important function for RNA editing.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-10698736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-10748081,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-10827456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-11251122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-1330537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-15691655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-1688737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-1693545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-1694178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-1812789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-2140530,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-2149743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-2160860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-2393904,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-2452697,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-2779560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-2844415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-3019552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-3568129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-7581322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-7984417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17008930-8703045
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1469-221X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1128-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17008930-Amino Acid Sequence,
pubmed-meshheading:17008930-Animals,
pubmed-meshheading:17008930-Base Sequence,
pubmed-meshheading:17008930-Electron Transport Complex IV,
pubmed-meshheading:17008930-Microscopy, Fluorescence,
pubmed-meshheading:17008930-Molecular Sequence Data,
pubmed-meshheading:17008930-RNA, Guide,
pubmed-meshheading:17008930-RNA, Messenger,
pubmed-meshheading:17008930-RNA, Protozoan,
pubmed-meshheading:17008930-RNA Editing,
pubmed-meshheading:17008930-Sequence Homology, Amino Acid,
pubmed-meshheading:17008930-Trypanosoma brucei brucei
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pubmed:year |
2006
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pubmed:articleTitle |
Alternative editing of cytochrome c oxidase III mRNA in trypanosome mitochondria generates protein diversity.
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pubmed:affiliation |
Program in Global Infectious Diseases, Josephine Bay Paul Center, Marine Biological Laboratory, 7 MBL Street, Woods Hole, Massachusetts 02543, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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