Source:http://linkedlifedata.com/resource/pubmed/id/17008425
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2007-2-7
|
| pubmed:abstractText |
Corneal epithelial stem cells are known to be localized to the basal layer of the limbal epithelium, providing a model system for epithelial stem cell biology; however, the mechanisms regarding the maintenance of these stem cells in their specialized niche remain poorly understood. N-cadherin is a member of the classic cadherin family and has previously been demonstrated to be expressed by hematopoietic stem cells. In the present study, we demonstrate that N-cadherin is expressed by putative stem/progenitor cells, as well as melanocytes, in the human limbal epithelial stem cell niche. In addition, we demonstrate that upon in vitro culture using 3T3 feeder layers, loss of N-cadherin expression occurs with cell proliferation. These results indicate that N-cadherin may be a critical cell-to-cell adhesion molecule between corneal epithelial stem/progenitor cells and their corresponding niche cells in the limbal epithelium.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1066-5099
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
289-96
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| pubmed:meshHeading |
pubmed-meshheading:17008425-Adult,
pubmed-meshheading:17008425-Animals,
pubmed-meshheading:17008425-Biological Markers,
pubmed-meshheading:17008425-Cadherins,
pubmed-meshheading:17008425-Cell Differentiation,
pubmed-meshheading:17008425-Cell Proliferation,
pubmed-meshheading:17008425-Colony-Forming Units Assay,
pubmed-meshheading:17008425-Epithelium, Corneal,
pubmed-meshheading:17008425-Flow Cytometry,
pubmed-meshheading:17008425-Gene Expression Regulation,
pubmed-meshheading:17008425-Humans,
pubmed-meshheading:17008425-Limbus Corneae,
pubmed-meshheading:17008425-Melanocytes,
pubmed-meshheading:17008425-Mice,
pubmed-meshheading:17008425-Middle Aged,
pubmed-meshheading:17008425-Models, Biological,
pubmed-meshheading:17008425-NIH 3T3 Cells,
pubmed-meshheading:17008425-Protein Transport,
pubmed-meshheading:17008425-RNA, Messenger,
pubmed-meshheading:17008425-Stem Cells
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
N-Cadherin is expressed by putative stem/progenitor cells and melanocytes in the human limbal epithelial stem cell niche.
|
| pubmed:affiliation |
Department of Ophthalmology, Tohoku University School of Medicine, 1-1 Seiryomachi, Aoba-ku, Sendai 980-8574, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|