Linked Life Data

17006633

Source:http://linkedlifedata.com/resource/pubmed/id/17006633

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-12-15
pubmed:abstractText
Echocardiography is an essential diagnostic tool for accurate noninvasive assessment of cardiac structure and function in vivo. However, the use of anesthetic agents during echocardiographic studies is associated with alterations in cardiac anatomical and functional parameters. We sought to systematically compare the effects of three commonly used anesthetic agents on echocardiographic measurements of left ventricular (LV) systolic and diastolic function, LV dimensions, and LV mass in rats. Adult male Fischer 344 rats underwent echocardiographic studies under pentobarbital (PB, 25 mg/kg i.p.) (group I, n = 25), inhaled isoflurane (ISF, 1.5%) (group II, n = 25),or ketamine/xylazine (K/X, 37 mg/kg ketamine and 7 mg/kg xylazine i.p.) (group III, n = 25) anesthesia in a cross-over design. Echocardiography was also performed in an additional group of unanesthetized conscious rats (group IV, n = 5). Postmortem studies were performed to validate echocardiographic assessment of LV dimension and mass. Rats in group I exhibited significantly higher LV ejection fraction, fractional shortening, fractional area change, velocity of circumferential fiber shortening corrected for heart rate, and heart rate as compared with groups II and III. LV end-diastolic volume, end-diastolic diameter, and cross-sectional area in diastole were significantly smaller in group I compared with groups II and III. Cardiac output was significantly lower in group III compared with groups I and II. Postmortem LV mass measurements correlated well with echocardiographic estimation of LV mass for all anesthetic agents, and the correlation was best with PB anesthesia. Limited echocardiographic data obtained in conscious rats were similar to those obtained under PB anesthesia. We conclude that compared with ISF and K/X anesthesia, PB anesthesia at a lower dose yields echocardiographic LV structural and functional data similar to those obtained in conscious rats. In addition, PB anesthesia also facilitates more accurate estimation of LV mass.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0300-8428
pubmed:author
pubmed:issnType
Print
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
28-41
pubmed:dateRevised
2009-11-3
pubmed:meshHeading
pubmed-meshheading:17006633-Anesthetics, General, pubmed-meshheading:17006633-Animals, pubmed-meshheading:17006633-Body Temperature, pubmed-meshheading:17006633-Body Weight, pubmed-meshheading:17006633-Diastole, pubmed-meshheading:17006633-Echocardiography, Doppler, pubmed-meshheading:17006633-Heart, pubmed-meshheading:17006633-Heart Rate, pubmed-meshheading:17006633-Heart Ventricles, pubmed-meshheading:17006633-Hypnotics and Sedatives, pubmed-meshheading:17006633-Isoflurane, pubmed-meshheading:17006633-Ketamine, pubmed-meshheading:17006633-Male, pubmed-meshheading:17006633-Organ Size, pubmed-meshheading:17006633-Phenobarbital, pubmed-meshheading:17006633-Rats, pubmed-meshheading:17006633-Rats, Inbred F344, pubmed-meshheading:17006633-Systole, pubmed-meshheading:17006633-Ventricular Function, Left, pubmed-meshheading:17006633-Xylazine
pubmed:year
2007
pubmed:articleTitle
Effects of anesthesia on echocardiographic assessment of left ventricular structure and function in rats.
pubmed:affiliation
Institute of Molecular Cardiology, University of Louisville, KY 40292, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural