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pubmed-article:17006327pubmed:abstractTextEx vivo liver gene therapy provides an attractive alternative to orthotopic liver transplantation for the treatment of liver diseases. We previously reported a protocol in which human primary hepatocytes are highly transduced in Suspension with Lentiviral vectors and Immediately Transplanted (SLIT). Here, we evaluated the SLIT approach in Gunn rats, the animal model for Crigler-Najjar syndrome type 1, a defect in bilirubin UDP-glucuronosyltransferase (BUGT).lld:pubmed
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pubmed-article:17006327pubmed:articleTitleEx vivo lentivirus transduction and immediate transplantation of uncultured hepatocytes for treating hyperbilirubinemic Gunn rat.lld:pubmed
pubmed-article:17006327pubmed:affiliationDepartment of Microbiology and Molecular Medicine, University of Geneva Medical Center, Geneva, Switzerland, and Service de biochimie, Hôpital Saint Joseph, Paris, France. Tuan.Nguyen@medecine.unige.chlld:pubmed
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