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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-9-28
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pubmed:abstractText |
Ex vivo liver gene therapy provides an attractive alternative to orthotopic liver transplantation for the treatment of liver diseases. We previously reported a protocol in which human primary hepatocytes are highly transduced in Suspension with Lentiviral vectors and Immediately Transplanted (SLIT). Here, we evaluated the SLIT approach in Gunn rats, the animal model for Crigler-Najjar syndrome type 1, a defect in bilirubin UDP-glucuronosyltransferase (BUGT).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
794-803
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17006327-Animals,
pubmed-meshheading:17006327-Base Sequence,
pubmed-meshheading:17006327-Cell Line,
pubmed-meshheading:17006327-Disease Models, Animal,
pubmed-meshheading:17006327-Genetic Vectors,
pubmed-meshheading:17006327-Green Fluorescent Proteins,
pubmed-meshheading:17006327-HeLa Cells,
pubmed-meshheading:17006327-Hepatocytes,
pubmed-meshheading:17006327-Humans,
pubmed-meshheading:17006327-Hyperbilirubinemia,
pubmed-meshheading:17006327-Kidney,
pubmed-meshheading:17006327-Lentivirus,
pubmed-meshheading:17006327-Liver,
pubmed-meshheading:17006327-Male,
pubmed-meshheading:17006327-Promoter Regions, Genetic,
pubmed-meshheading:17006327-RNA, Messenger,
pubmed-meshheading:17006327-RNA, Viral,
pubmed-meshheading:17006327-Rats,
pubmed-meshheading:17006327-Rats, Gunn,
pubmed-meshheading:17006327-Transplantation, Isogeneic
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pubmed:year |
2006
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pubmed:articleTitle |
Ex vivo lentivirus transduction and immediate transplantation of uncultured hepatocytes for treating hyperbilirubinemic Gunn rat.
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pubmed:affiliation |
Department of Microbiology and Molecular Medicine, University of Geneva Medical Center, Geneva, Switzerland, and Service de biochimie, Hôpital Saint Joseph, Paris, France. Tuan.Nguyen@medecine.unige.ch
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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