Source:http://linkedlifedata.com/resource/pubmed/id/17005627
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2007-1-9
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| pubmed:abstractText |
After identifying an association between maternal Epstein-Barr virus (EBV) reactivation and acute lymphoblastic leukemia (ALL), the authors analyzed a nested case-control study within Finnish and Icelandic maternity cohorts with 7 million years of follow-up to confirm EBV's role in ALL. Offspring of 550,000 mothers were followed up to age 15 years during 1975-1997 by national cancer registries to identify leukemia cases. Mothers of cases and three quarters of matched mothers of controls were identified by national population registers. First-trimester sera from mothers of 304 ALL cases and 39 non-ALL cases and from 943 mothers of controls were analyzed for antibodies to viral capsid antigen, early antigen, and EBV transactivator protein ZEBRA. Relative risk, estimated as odds ratio (95% confidence interval), was adjusted for birth order and sibship size. Combining early antigen and/or ZEBRA immunoglobulin G antibodies with the presence of viral capsid antigen immunoglobulin M antibodies did not increase the estimate for ALL risk for viral capsid antigen immunoglobulin M alone (odds ratio = 1.9, 95% confidence interval: 1.2, 3.0). Both ZEBRA immunoglobulin G antibodies and viral capsid antigen immunoglobulin M antibodies were associated with an increased risk of non-ALL in the offspring (odds ratio = 4.5, 95% confidence interval: 1.3, 16; odds ratio = 5.6, 95% confidence interval: 1.1, 29, respectively), suggesting EBV reactivation in the mothers of non-ALL cases. EBV reactivation may be associated with a proportion of childhood leukemia.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Anti-Idiotypic,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Capsid Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Epstein-Barr viral capsid antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0002-9262
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| pubmed:author |
pubmed-author:BloiguAiniA,
pubmed-author:DillnerJoakimJ,
pubmed-author:GudnadottirMargretM,
pubmed-author:KoskelaPenttiP,
pubmed-author:LehtinenMattiM,
pubmed-author:LehtinenTuulaT,
pubmed-author:MarusAlessiaA,
pubmed-author:OgmundsdottirHelga MHM,
pubmed-author:PukkalaEeroE,
pubmed-author:TedeschiRosamariaR,
pubmed-author:dePaoliPaoloP
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
165
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
134-7
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:17005627-Adolescent,
pubmed-meshheading:17005627-Antibodies, Anti-Idiotypic,
pubmed-meshheading:17005627-Antigens, Viral,
pubmed-meshheading:17005627-Capsid Proteins,
pubmed-meshheading:17005627-Child,
pubmed-meshheading:17005627-Child, Preschool,
pubmed-meshheading:17005627-Epstein-Barr Virus Infections,
pubmed-meshheading:17005627-Female,
pubmed-meshheading:17005627-Finland,
pubmed-meshheading:17005627-Follow-Up Studies,
pubmed-meshheading:17005627-Herpesvirus 4, Human,
pubmed-meshheading:17005627-Humans,
pubmed-meshheading:17005627-Iceland,
pubmed-meshheading:17005627-Immunoglobulin G,
pubmed-meshheading:17005627-Incidence,
pubmed-meshheading:17005627-Infant,
pubmed-meshheading:17005627-Infant, Newborn,
pubmed-meshheading:17005627-Maternal Exposure,
pubmed-meshheading:17005627-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:17005627-Retrospective Studies,
pubmed-meshheading:17005627-Risk Factors,
pubmed-meshheading:17005627-Time Factors
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| pubmed:year |
2007
|
| pubmed:articleTitle |
Activation of maternal Epstein-Barr virus infection and risk of acute leukemia in the offspring.
|
| pubmed:affiliation |
Department of Microbiology, Oncological Center, Aviano, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|