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rdf:type |
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lifeskim:mentions |
umls-concept:C0003009,
umls-concept:C0205314,
umls-concept:C0205431,
umls-concept:C0220781,
umls-concept:C0243126,
umls-concept:C0390423,
umls-concept:C0597357,
umls-concept:C0679622,
umls-concept:C0920591,
umls-concept:C1332036,
umls-concept:C1412113,
umls-concept:C1510827,
umls-concept:C1705845,
umls-concept:C1707689,
umls-concept:C1883254
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pubmed:issue |
20
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pubmed:dateCreated |
2006-9-28
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pubmed:abstractText |
A benzodiazepine-based beta-turn mimetic has been designed, synthesized, and incorporated into angiotensin II. Comparison of the mimetic with beta-turns in crystallized proteins showed that it most closely resembles a type II beta-turn. The compounds exhibited high to moderate binding affinity for the AT2 receptor, and one also displayed high affinity for the AT1 receptor. Molecular modeling showed that the high-affinity compounds could be incorporated into a previously derived model of AT2 receptor ligands.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
49
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6133-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17004728-Angiotensin II,
pubmed-meshheading:17004728-Animals,
pubmed-meshheading:17004728-Aorta, Thoracic,
pubmed-meshheading:17004728-Benzodiazepines,
pubmed-meshheading:17004728-Drug Design,
pubmed-meshheading:17004728-Female,
pubmed-meshheading:17004728-Ligands,
pubmed-meshheading:17004728-Liver,
pubmed-meshheading:17004728-Models, Molecular,
pubmed-meshheading:17004728-Molecular Mimicry,
pubmed-meshheading:17004728-Muscle, Smooth, Vascular,
pubmed-meshheading:17004728-Muscle Contraction,
pubmed-meshheading:17004728-Peptides,
pubmed-meshheading:17004728-Protein Structure, Secondary,
pubmed-meshheading:17004728-Rabbits,
pubmed-meshheading:17004728-Radioligand Assay,
pubmed-meshheading:17004728-Rats,
pubmed-meshheading:17004728-Receptor, Angiotensin, Type 1,
pubmed-meshheading:17004728-Receptor, Angiotensin, Type 2,
pubmed-meshheading:17004728-Swine,
pubmed-meshheading:17004728-Uterus
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pubmed:year |
2006
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pubmed:articleTitle |
Design, synthesis, and incorporation of a beta-turn mimetic in angiotensin II forming novel pseudopeptides with affinity for AT1 and AT2 receptors.
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pubmed:affiliation |
Department of Medicinal Chemistry, BMC, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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