Source:http://linkedlifedata.com/resource/pubmed/id/17003850
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
2006-9-27
|
| pubmed:abstractText |
The metabolism of melatonin to 6-sulphatoxymelatonin (aMT6S) and N-acetylserotonin (NAS) is catalyzed by cytochrome-P450 (CYP) isozymes CYP1A2 and CYP2C19 respectively. We studied the in vivo effect of CYP2C19 substrate (citalopram, omepratzole, or lansopratzole) on the metabolism of endogenous and exogenous melatonin by measuring the excretion of urinary aMT6S, the main metabolite of melatonin, and a reliable estimate of plasma melatonin in 15 insomniac psychogeriatric inpatients. The effect of melatonin treatment on sleep parameters was also assessed. The patients with or without CYP2C19 substrate were treated for 21 days randomly in a double-blind manner with placebo or 2 mg exogenous melatonin orally. aMT6S excretions were measured radioimmunologically from night urine at baseline (day 0), on day 21, and one day after the treatment was discontinued (day 22). Sleep parameters were assessed using the Sleep Assessment Scale and the Sleep Quality Scale. In the control patients receiving only melatonin, aMT6S excretion increased 72-fold and returned to baseline on day 22. In the patients receiving melatonin + CYP2C19 substrate, aMT6S excretion increased 156-fold and was, on day 22, still 6.4-fold higher than at baseline (p = 0.04). The 22/0 day aMT6S excretion ratio was 10-fold higher in the patients treated with melatonin + CYP2C19 substrate when compared with that in the subjects treated with placebo + CYP2C19 substrate (p = 0.02). CYP2C19 substrate did not affect the metabolism of endogenous melatonin. The sleep parameters in the patients on melatonin treatment did not differ from those in the patients treated with placebo. In conclusion, it may be inferred that CYP2C19 substrate slows the metabolism of exogenous melatonin and increases its bioavailability, as shown by the augmented excretion of aMT6S, probably by inhibiting the conversion of melatonin to NAS via CYP2C19 isozyme. Melatonin therapy may not affect the sleep parameters in our psychogeriatric inpatients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-Pyridinylmethylsulfinylbenzimidazo...,
http://linkedlifedata.com/resource/pubmed/chemical/6-sulfatoxymelatonin,
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/CYP2C19 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Citalopram,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Melatonin,
http://linkedlifedata.com/resource/pubmed/chemical/Mixed Function Oxygenases,
http://linkedlifedata.com/resource/pubmed/chemical/Omeprazole,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Uptake Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/lansoprazole
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0379-0355
|
| pubmed:author | |
| pubmed:copyrightInfo |
(c) 2006 Prous Science. All rights reserved.
|
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
447-50
|
| pubmed:meshHeading |
pubmed-meshheading:17003850-2-Pyridinylmethylsulfinylbenzimidazoles,
pubmed-meshheading:17003850-Aged,
pubmed-meshheading:17003850-Aged, 80 and over,
pubmed-meshheading:17003850-Anticonvulsants,
pubmed-meshheading:17003850-Antidepressive Agents, Second-Generation,
pubmed-meshheading:17003850-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:17003850-Citalopram,
pubmed-meshheading:17003850-Double-Blind Method,
pubmed-meshheading:17003850-Drug Therapy, Combination,
pubmed-meshheading:17003850-Enzyme Inhibitors,
pubmed-meshheading:17003850-Female,
pubmed-meshheading:17003850-Humans,
pubmed-meshheading:17003850-Male,
pubmed-meshheading:17003850-Melatonin,
pubmed-meshheading:17003850-Mental Disorders,
pubmed-meshheading:17003850-Mixed Function Oxygenases,
pubmed-meshheading:17003850-Omeprazole,
pubmed-meshheading:17003850-Serotonin Uptake Inhibitors,
pubmed-meshheading:17003850-Sleep Disorders,
pubmed-meshheading:17003850-Time Factors,
pubmed-meshheading:17003850-Treatment Outcome
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
The effect of CYP2C19 substrate on the metabolism of melatonin in the elderly: A randomized, double-blind, placebo-controlled study.
|
| pubmed:affiliation |
Department of Psychogeriatrics, Tampere University Hospital, Tampere, Finland. kaija.huuhka@pshp.fi
|
| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial
|