Source:http://linkedlifedata.com/resource/pubmed/id/17003363
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2006-9-27
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pubmed:abstractText |
We examined the association between alpha-adducin 1 (ADD1) gene polymorphism (Gly460Trp) with macrovascular complications and mortality in type 2 diabetes in a Caucasian population aged >or=55 years. The study was part of the Rotterdam Study, a prospective population-based cohort study. ADD1 polymorphism was determined in 6,471 participants, including 599 patients with type 2 diabetes at baseline. The prevalence of hypertension in type 2 diabetic patients was 2.57 times higher in ADD1 TT carriers compared with GG carriers (95% CI 1.05-6.32, P = 0.03). Homozygous T carriers also had a higher mean common carotid intima media thickness (IMT) compared with GG carriers (mean difference 0.05 mm, P for trend = 0.03). In diabetic patients with hypertension, the risk of mortality was 1.83 times higher in homozygous T carriers compared with the GG genotype group (95% CI 1.07-3.16, P = 0.03). The increased risk was only present among TT carriers who did not use antidiabetes medication (hazard ratio 2.18 [95% CI 1.12-4.24], P = 0.02). The results of this population-based cohort study suggest that the ADD1 gene contributes to the risk of hypertension and increases mean common carotid IMT in patients with type 2 diabetes. Furthermore, the study indicates that the ADD1 polymorphism could be useful in identifying hypertensive type 2 diabetic patients with a high risk of mortality.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0012-1797
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pubmed:author |
pubmed-author:AulchenkoYurii SYS,
pubmed-author:HofmanAlbertA,
pubmed-author:JanssenJoop A M J LJA,
pubmed-author:LambertsSteven W JSW,
pubmed-author:OostraBen ABA,
pubmed-author:PolsHuibert A PHA,
pubmed-author:Sayed-TabatabaeiFakhredin AFA,
pubmed-author:StrickerBruno H CBH,
pubmed-author:WittemanJacqueline C MJC,
pubmed-author:YazdanpanahMojganM,
pubmed-author:van DuijnCornelia MCM
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2922-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:17003363-Aged,
pubmed-meshheading:17003363-Calmodulin-Binding Proteins,
pubmed-meshheading:17003363-Diabetes Mellitus, Type 2,
pubmed-meshheading:17003363-Diabetic Angiopathies,
pubmed-meshheading:17003363-Female,
pubmed-meshheading:17003363-Humans,
pubmed-meshheading:17003363-Hypertension,
pubmed-meshheading:17003363-Male,
pubmed-meshheading:17003363-Middle Aged,
pubmed-meshheading:17003363-Netherlands,
pubmed-meshheading:17003363-Prevalence
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pubmed:year |
2006
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pubmed:articleTitle |
The alpha-adducin gene is associated with macrovascular complications and mortality in patients with type 2 diabetes.
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pubmed:affiliation |
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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