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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-10-30
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pubmed:abstractText |
The integrin alphavbeta3 is an adhesion molecule expressed by proliferating endothelial cells and antibodies blocking this integrin inhibit angiogenesis in preclinical models. MEDI-522 is a second generation humanized anti-alphavbeta3 antibody designed for antiangiogenic therapy. The purpose of this study was to examine potential effects of this agent on blood vessels.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0167-6997
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-55
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17001523-Adult,
pubmed-meshheading:17001523-Angiogenesis Inhibitors,
pubmed-meshheading:17001523-Antibodies, Monoclonal,
pubmed-meshheading:17001523-Apoptosis,
pubmed-meshheading:17001523-Blood Vessels,
pubmed-meshheading:17001523-Dose-Response Relationship, Drug,
pubmed-meshheading:17001523-Drug Administration Schedule,
pubmed-meshheading:17001523-Endothelium, Vascular,
pubmed-meshheading:17001523-Fluorescent Antibody Technique,
pubmed-meshheading:17001523-Focal Adhesion Kinase 1,
pubmed-meshheading:17001523-Humans,
pubmed-meshheading:17001523-Image Processing, Computer-Assisted,
pubmed-meshheading:17001523-Infusions, Intravenous,
pubmed-meshheading:17001523-Integrin alphaVbeta3,
pubmed-meshheading:17001523-Lymphoma,
pubmed-meshheading:17001523-Neoplasms,
pubmed-meshheading:17001523-Neovascularization, Pathologic,
pubmed-meshheading:17001523-Skin,
pubmed-meshheading:17001523-Time Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Effects of a monoclonal anti-alphavbeta3 integrin antibody on blood vessels - a pharmacodynamic study.
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pubmed:affiliation |
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53792, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial, Phase I,
Research Support, N.I.H., Extramural
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