rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
14
|
pubmed:dateCreated |
2006-10-3
|
pubmed:abstractText |
Noninvasive imaging of adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) may identify early stages of inflammation in atherosclerosis. We hypothesized that a novel, second-generation VCAM-1-targeted agent with enhanced affinity had sufficient sensitivity to enable real-time detection of VCAM-1 expression in experimental atherosclerosis in vivo, to quantify pharmacotherapy-induced reductions in VCAM-1 expression, and to identify activated cells in human plaques.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
1524-4539
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:day |
3
|
pubmed:volume |
114
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1504-11
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:17000904-Amino Acid Sequence,
pubmed-meshheading:17000904-Animals,
pubmed-meshheading:17000904-Apolipoproteins E,
pubmed-meshheading:17000904-Atherosclerosis,
pubmed-meshheading:17000904-Diagnostic Imaging,
pubmed-meshheading:17000904-Down-Regulation,
pubmed-meshheading:17000904-Drug Monitoring,
pubmed-meshheading:17000904-Gene Expression Regulation,
pubmed-meshheading:17000904-Inflammation,
pubmed-meshheading:17000904-Ligands,
pubmed-meshheading:17000904-Magnetic Resonance Imaging,
pubmed-meshheading:17000904-Mice,
pubmed-meshheading:17000904-Mice, Knockout,
pubmed-meshheading:17000904-Peptides,
pubmed-meshheading:17000904-Vascular Cell Adhesion Molecule-1
|
pubmed:year |
2006
|
pubmed:articleTitle |
Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis.
|
pubmed:affiliation |
Center for Molecular Imaging Research, Massachusetts General Hospital, Boston, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|