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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2006-9-26
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pubmed:abstractText |
PI-88 is a mixture of highly sulfated oligosaccharides that inhibits heparanase, an extracellular matrix endoglycosidase, and the binding of angiogenic growth factors to heparan sulfate. This agent showed potent inhibition of placental blood vessel angiogenesis as well as growth inhibition in multiple xenograft models, thus forming the basis for this study.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:AddisonRussell SRS,
pubmed-author:BascheMicheleM,
pubmed-author:CreeseBrian RBR,
pubmed-author:DavisKatK,
pubmed-author:EckhardtS GailSG,
pubmed-author:GoreLiaL,
pubmed-author:GustafsonDaniel LDL,
pubmed-author:HoldenScott NSN,
pubmed-author:KangasMichaelM,
pubmed-author:LevinAdrahA,
pubmed-author:MooreJane CJC,
pubmed-author:MorrowMarkM,
pubmed-author:NguyenThuT,
pubmed-author:O'BryantCindy LCL,
pubmed-author:RobertsKayeK,
pubmed-author:SchultzMary KayMK,
pubmed-author:WittaSamirS
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5471-80
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pubmed:dateRevised |
2007-5-2
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pubmed:meshHeading |
pubmed-meshheading:17000682-Adult,
pubmed-meshheading:17000682-Aged,
pubmed-meshheading:17000682-Antibody Formation,
pubmed-meshheading:17000682-Antineoplastic Agents,
pubmed-meshheading:17000682-Carcinoid Tumor,
pubmed-meshheading:17000682-Carcinoma, Renal Cell,
pubmed-meshheading:17000682-Colorectal Neoplasms,
pubmed-meshheading:17000682-Female,
pubmed-meshheading:17000682-Fibroblast Growth Factors,
pubmed-meshheading:17000682-Glucuronidase,
pubmed-meshheading:17000682-Humans,
pubmed-meshheading:17000682-Leiomyosarcoma,
pubmed-meshheading:17000682-Male,
pubmed-meshheading:17000682-Maximum Tolerated Dose,
pubmed-meshheading:17000682-Melanoma,
pubmed-meshheading:17000682-Middle Aged,
pubmed-meshheading:17000682-Neoplasms,
pubmed-meshheading:17000682-Oligosaccharides,
pubmed-meshheading:17000682-Partial Thromboplastin Time,
pubmed-meshheading:17000682-Vascular Endothelial Growth Factor A
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pubmed:year |
2006
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pubmed:articleTitle |
A phase I biological and pharmacologic study of the heparanase inhibitor PI-88 in patients with advanced solid tumors.
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pubmed:affiliation |
University of Colorado Cancer Center, Aurora, Colorado 80010, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I
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